- MCAT score range?
- 472–528 total, with each of the 4 sections scored 118–132 (midpoint 500/125).
- Powerhouse of the cell?
- The mitochondria — site of the Krebs cycle and electron transport chain, making most ATP.
- How many amino acids are proteinogenic?
- 20 standard amino acids, each with the same backbone but a unique R-group (side chain).
- Ideal gas law?
- PV = nRT, where R = 0.0821 L·atm/mol·K (or 8.314 J/mol·K). Use absolute temperature in kelvin.
- Newton's second law?
- F = ma — net force equals mass times acceleration. Force in newtons (N = kg·m/s²).
- What is classical conditioning?
- Learning by pairing a neutral stimulus with an unconditioned stimulus until it triggers a conditioned response (Pavlov).
- SN1 vs SN2 — rate order?
- SN1 is first-order (rate = k[substrate]); SN2 is second-order (rate = k[substrate][nucleophile]).
- Henderson-Hasselbalch equation?
- pH = pKa + log([A⁻]/[HA]). At the half-equivalence point, pH = pKa.
- Durkheim's key concept?
- Anomie — a breakdown of social norms and regulation; foundational to functionalist sociology.
- CARS — golden rule?
- Answer only from the passage. The right choice is supported by the text; outside knowledge is a trap.
- Steps of aerobic respiration?
- Glycolysis (cytoplasm) → pyruvate oxidation → Krebs cycle → electron transport chain (mitochondria). Total ≈ 30–32 ATP/glucose.
- Where does glycolysis occur?
- The cytoplasm. Glucose (6C) splits into 2 pyruvate, netting 2 ATP and 2 NADH; no oxygen required.
- Final electron acceptor in the ETC?
- Oxygen (O₂). It accepts spent electrons and combines with H⁺ to form water in oxidative phosphorylation.
- Mitosis vs meiosis?
- Mitosis makes 2 identical diploid cells (growth/repair). Meiosis makes 4 unique haploid gametes (reproduction) via 2 divisions.
- Phases of mitosis (PMAT)?
- Prophase, Metaphase, Anaphase, Telophase (after interphase); cytokinesis splits the cytoplasm.
- What happens in S phase?
- DNA replication — the cell copies its genome so each daughter cell receives a full set of chromosomes.
- Central dogma of molecular biology?
- DNA → (transcription) → RNA → (translation) → protein. Information flows from gene to functional product.
- Where does transcription occur in eukaryotes?
- The nucleus. RNA polymerase synthesizes mRNA from a DNA template; it is then processed and exported.
- Where does translation occur?
- At ribosomes in the cytoplasm (or on the rough ER). tRNA delivers amino acids matching mRNA codons.
- Start and stop codons?
- Start: AUG (methionine). Stop: UAA, UAG, UGA — no amino acid; they terminate translation.
- Function of the Golgi apparatus?
- Modifies, sorts, and packages proteins and lipids from the ER into vesicles for secretion or delivery.
- Function of lysosomes?
- Membrane-bound organelles full of hydrolytic enzymes that digest macromolecules, debris, and worn organelles.
- Rough vs smooth ER?
- Rough ER (ribosome-studded) makes/processes proteins; smooth ER makes lipids, stores Ca²⁺, and detoxifies.
- Path of blood through the heart?
- Body → vena cava → RA → tricuspid → RV → pulmonary artery → lungs → pulmonary vein → LA → mitral → LV → aorta → body.
- LAB RAT (heart valves)?
- Left = Bicuspid (mitral), Right = Tricuspid — the two atrioventricular valves.
- Strongest chamber of the heart?
- The left ventricle — it pumps oxygenated blood out the aorta to the whole body against high pressure.
- Which side of the heart carries oxygenated blood?
- The left side. The right side handles deoxygenated blood; the pulmonary vessels are the famous exceptions.
- Function of the nephron?
- The kidney's functional unit — it filters blood and forms urine via filtration, reabsorption, and secretion.
- Order of nephron flow?
- Bowman's capsule → proximal tubule → loop of Henle → distal tubule → collecting duct.
- Role of ADH (vasopressin)?
- Increases water reabsorption in the collecting duct, concentrating urine and conserving body water.
- Role of aldosterone?
- Increases Na⁺ (and water) reabsorption and K⁺ secretion in the distal nephron, raising blood pressure.
- Resting membrane potential of a neuron?
- About −70 mV, maintained by the Na⁺/K⁺ pump (3 Na⁺ out, 2 K⁺ in) and leak channels.
- What triggers an action potential?
- Depolarization to threshold (~ −55 mV) opens voltage-gated Na⁺ channels, causing a rapid spike.
- Saltatory conduction?
- Action potentials jumping node to node between myelin sheaths, greatly speeding nerve conduction.
- Sympathetic vs parasympathetic?
- Sympathetic = 'fight or flight' (raises heart rate). Parasympathetic = 'rest and digest' (lowers it).
- Endocrine vs exocrine glands?
- Endocrine glands secrete hormones into the blood; exocrine glands secrete via ducts (e.g., sweat, saliva).
- Insulin vs glucagon?
- Insulin lowers blood glucose (uptake/storage); glucagon raises it (glycogen breakdown). Both from the pancreas.
- Negative feedback loop?
- A response that opposes the initial change to restore homeostasis — e.g., thermoregulation, blood glucose control.
- Mendel's law of segregation?
- Each parent's two alleles separate during gamete formation, so each gamete carries one allele per gene.
- Mendel's law of independent assortment?
- Alleles of different genes assort independently during gamete formation (genes on separate chromosomes).
- Genotype vs phenotype?
- Genotype is the genetic makeup (alleles); phenotype is the observable trait it produces.
- Homozygous vs heterozygous?
- Homozygous = two identical alleles (AA or aa); heterozygous = two different alleles (Aa).
- Hardy-Weinberg equations?
- p + q = 1 and p² + 2pq + q² = 1, where p² and q² are homozygotes and 2pq the heterozygotes.
- Conditions for Hardy-Weinberg equilibrium?
- No mutation, no migration, no selection, random mating, and a large population. Violation means evolution.
- Sources of genetic variation in meiosis?
- Crossing over (prophase I), independent assortment, and random fertilization.
- Prokaryote vs eukaryote?
- Prokaryotes lack a nucleus and membrane-bound organelles; eukaryotes have both. Bacteria are prokaryotes.
- What is the lac operon?
- An inducible bacterial gene cluster for lactose metabolism; allolactose inactivates the repressor to allow transcription.
- Stages of viral lytic vs lysogenic cycle?
- Lytic: replicate and burst the host. Lysogenic: integrate as a prophage and lie dormant until induced.
- Innate vs adaptive immunity?
- Innate is fast and nonspecific (barriers, phagocytes); adaptive is slower, specific, and has memory (B and T cells).
- B cells vs T cells?
- B cells make antibodies (humoral immunity); T cells coordinate/kill infected cells (cell-mediated immunity).
- What is gluconeogenesis?
- Synthesis of glucose from non-carbohydrate precursors (lactate, glycerol, amino acids), mainly in the liver.
- Function of the placenta?
- Exchanges gases, nutrients, and wastes between mother and fetus, and secretes hormones (hCG, progesterone).
- Stages of embryonic development?
- Zygote → cleavage → blastula → gastrula (forms 3 germ layers) → organogenesis.
- Three germ layers and a derivative of each?
- Ectoderm (skin/nervous system), mesoderm (muscle/bone/blood), endoderm (gut/lung lining).
- Spermatogenesis vs oogenesis?
- Spermatogenesis makes 4 sperm per cell continuously; oogenesis makes 1 egg (+ polar bodies) cyclically.
- Role of FSH and LH in the menstrual cycle?
- FSH grows the follicle; the LH surge triggers ovulation. Both come from the anterior pituitary.
- Cori cycle?
- Lactate from anaerobic muscle travels to the liver, is converted to glucose, and returns to muscle.
- What is fermentation?
- Anaerobic regeneration of NAD⁺ so glycolysis can continue — producing lactate (animals) or ethanol + CO₂ (yeast).
- Skeletal vs cardiac vs smooth muscle?
- Skeletal: striated, voluntary. Cardiac: striated, involuntary, has intercalated discs. Smooth: nonstriated, involuntary.
- Sliding filament theory?
- Muscle contracts as actin slides over myosin, pulling Z-lines together; Ca²⁺ and ATP are required.
- Function of surfactant in the lungs?
- Reduces surface tension in alveoli, preventing their collapse and easing inflation.
- What is the Bohr effect?
- Higher CO₂/lower pH shifts hemoglobin's O₂ curve right, releasing more oxygen to active tissues.
- Function of the liver (3 examples)?
- Detoxification, bile production, glycogen storage, plasma protein synthesis, and urea formation.
- What is apoptosis?
- Programmed cell death — a controlled, ATP-dependent process for development and removing damaged cells.
- Operon regulation: inducible vs repressible?
- Inducible operons are normally off and turn on with an inducer; repressible operons are on and turn off with a corepressor.
- Four levels of protein structure?
- Primary (sequence), secondary (α-helices/β-sheets), tertiary (3D fold), quaternary (multiple subunits).
- What stabilizes secondary structure?
- Hydrogen bonds between backbone amide and carbonyl groups — forming α-helices and β-pleated sheets.
- What is a peptide bond?
- An amide bond between the carboxyl group of one amino acid and the amino group of the next, releasing water.
- The three nonpolar aliphatic amino acids to remember?
- Glycine, alanine, valine, leucine, isoleucine (and proline) are nonpolar — they bury in the protein core.
- Which amino acids are positively charged (basic)?
- Lysine, arginine, and histidine. Histidine's pKa near 6 makes it key in enzyme active sites.
- Which amino acids are negatively charged (acidic)?
- Aspartate and glutamate — their carboxylic acid side chains are deprotonated at physiological pH.
- What is the isoelectric point (pI)?
- The pH at which a molecule has no net charge. For an amino acid, pI is the average of the two relevant pKa values.
- Michaelis-Menten equation?
- v = (Vmax[S])/(Km + [S]). It describes the rate of an enzyme reaction versus substrate concentration.
- What does Km represent?
- The substrate concentration at half Vmax — an inverse measure of an enzyme's affinity (low Km = high affinity).
- What does a Lineweaver-Burk plot show?
- A double-reciprocal plot (1/v vs 1/[S]); y-intercept = 1/Vmax, x-intercept = −1/Km. Linearizes Michaelis-Menten.
- Competitive inhibition — effect on Km and Vmax?
- Increases apparent Km; Vmax unchanged. The inhibitor competes at the active site and is overcome by more substrate.
- Noncompetitive inhibition — effect on Km and Vmax?
- Decreases Vmax; Km unchanged. The inhibitor binds an allosteric site regardless of substrate.
- Feedback inhibition?
- The end product of a pathway inhibits an upstream enzyme, preventing overproduction (allosteric regulation).
- What is a cofactor vs coenzyme?
- Cofactors are nonprotein helpers; inorganic ones are metal ions, organic ones (often vitamin-derived) are coenzymes (e.g., NAD⁺).
- Rate-limiting enzyme of glycolysis?
- Phosphofructokinase-1 (PFK-1) — the key regulatory, committed step; inhibited by ATP and citrate.
- Net ATP/NADH of glycolysis?
- Per glucose: 2 ATP (net) and 2 NADH; 2 pyruvate are produced.
- Where does the Krebs cycle occur?
- The mitochondrial matrix. One acetyl-CoA yields 3 NADH, 1 FADH₂, 1 GTP, and 2 CO₂ per turn.
- What does the electron transport chain produce?
- A proton gradient that drives ATP synthase (chemiosmosis); most cellular ATP is made here.
- Glycogenesis vs glycogenolysis?
- Glycogenesis builds glycogen from glucose; glycogenolysis breaks glycogen down to release glucose.
- What is beta-oxidation?
- The breakdown of fatty acids into acetyl-CoA units in the mitochondria, feeding the Krebs cycle for energy.
- Saturated vs unsaturated fatty acids?
- Saturated have no C=C double bonds (solid, packed tightly); unsaturated have C=C kinks (liquid, less dense).
- Structure of a phospholipid?
- A polar phosphate head and two nonpolar fatty-acid tails — amphipathic, so it forms bilayers in water.
- Why do phospholipids form a bilayer?
- Hydrophobic tails cluster away from water while hydrophilic heads face it, minimizing free energy.
- What are the four major biomolecules?
- Carbohydrates, lipids, proteins, and nucleic acids.
- Glycosidic vs peptide vs phosphodiester bond?
- Glycosidic links sugars; peptide links amino acids; phosphodiester links nucleotides in DNA/RNA.
- DNA vs RNA — three differences?
- DNA: deoxyribose, thymine, double-stranded. RNA: ribose, uracil, usually single-stranded.
- Purines vs pyrimidines?
- Purines (A, G) are double-ringed; pyrimidines (C, T, U) are single-ringed. 'PURe As Gold.'
- Chargaff's rules / base pairing?
- A pairs with T (2 H-bonds), G pairs with C (3 H-bonds); so %A = %T and %G = %C.
- What is a glycoprotein?
- A protein with covalently attached carbohydrate chains — important in cell recognition and signaling.
- Enzymes lower what?
- The activation energy of a reaction, speeding it without being consumed or changing the equilibrium.
- Allosteric regulation?
- Binding at a site other than the active site changes enzyme shape/activity (activation or inhibition).
- Cooperativity in hemoglobin?
- O₂ binding to one subunit increases affinity of the others, giving a sigmoidal binding curve.
- What is Vmax?
- The maximum reaction rate when an enzyme is saturated with substrate; proportional to enzyme concentration.
- Pentose phosphate pathway — main products?
- NADPH (for biosynthesis) and ribose-5-phosphate (for nucleotides). It runs in the cytoplasm.
- What is the role of NADPH?
- An electron donor for biosynthesis (fatty acids, etc.) and antioxidant defense — distinct from NADH's catabolic role.
- Substrate-level vs oxidative phosphorylation?
- Substrate-level transfers a phosphate directly to ADP; oxidative uses the ETC proton gradient and ATP synthase.
- What is denaturation?
- Loss of a protein's 3D structure (and function) from heat, pH, or chemicals — the primary sequence stays intact.
- Three types of RNA in translation?
- mRNA (codons/message), tRNA (carries amino acids), rRNA (ribosome structure and catalysis).
- What does a kinase do?
- Transfers a phosphate group from ATP to a substrate (phosphorylation), often regulating activity.
- What does a phosphatase do?
- Removes a phosphate group (dephosphorylation) — often reversing a kinase's effect.
- What is the role of ATP?
- The cell's energy currency; hydrolysis of its high-energy phosphoanhydride bonds powers cellular work.
- Fischer projection — how is chirality shown?
- Horizontal lines point toward the viewer, vertical lines away; D/L sugars are assigned by the bottom chiral center.
- Define pH.
- pH = −log[H⁺]. Below 7 is acidic, 7 neutral, above 7 basic; pH + pOH = 14 at 25°C.
- Strong vs weak acid?
- Strong acids fully dissociate (HCl, H₂SO₄); weak acids only partly dissociate and have a characteristic Ka.
- What is Ka?
- The acid dissociation constant; a larger Ka (smaller pKa) means a stronger acid that dissociates more.
- Le Chatelier's principle?
- A system at equilibrium shifts to partly offset an imposed change in concentration, pressure, or temperature.
- Equilibrium constant Keq — meaning?
- Keq = [products]/[reactants] at equilibrium (with coefficients as exponents); >1 favors products, <1 favors reactants.
- Effect of a catalyst on equilibrium?
- It speeds both forward and reverse rates equally — reaching equilibrium faster but not changing its position.
- What is a buffer?
- A solution of a weak acid and its conjugate base that resists pH change; works best within ±1 pH of its pKa.
- Oxidation vs reduction (OIL RIG)?
- Oxidation Is Loss of electrons; Reduction Is Gain. They always occur together in a redox reaction.
- Oxidizing vs reducing agent?
- The oxidizing agent is reduced (gains e⁻); the reducing agent is oxidized (loses e⁻).
- Cathode vs anode?
- Reduction happens at the cathode; oxidation at the anode. ('Red Cat, An Ox.')
- Galvanic vs electrolytic cell?
- Galvanic: spontaneous, generates current (ΔG<0). Electrolytic: nonspontaneous, driven by external current (ΔG>0).
- Gibbs free energy equation?
- ΔG = ΔH − TΔS. ΔG<0 is spontaneous, ΔG>0 nonspontaneous, ΔG=0 at equilibrium.
- ΔG and spontaneity?
- Negative ΔG = spontaneous (exergonic); positive ΔG = nonspontaneous (endergonic).
- First law of thermodynamics?
- Energy is conserved: ΔU = q − w. Energy is neither created nor destroyed, only transferred.
- Second law of thermodynamics?
- The entropy of an isolated system tends to increase; spontaneous processes increase total disorder.
- Endothermic vs exothermic?
- Endothermic absorbs heat (ΔH>0); exothermic releases heat (ΔH<0).
- Hess's law?
- The total enthalpy change of a reaction is the sum of the enthalpy changes of its steps (a state function).
- Molarity formula?
- Molarity (M) = moles of solute / liters of solution.
- Dilution equation?
- M₁V₁ = M₂V₂ — moles of solute stay constant when you add solvent.
- What is a mole?
- 6.02×10²³ particles (Avogadro's number); the bridge between mass (grams) and number of particles.
- Steps of stoichiometry?
- Balance the equation, convert grams to moles, apply the mole (coefficient) ratio, then convert back.
- Limiting reactant — what is it?
- The reactant that runs out first; it caps how much product can form. Excess reactant is left over.
- Boyle's law?
- At constant T, P ∝ 1/V (P₁V₁ = P₂V₂). Squeezing a gas raises its pressure.
- Charles's law?
- At constant P, V ∝ T (V₁/T₁ = V₂/T₂), with T in kelvin. Heating a gas expands it.
- Colligative properties?
- Properties depending on particle count, not identity: boiling-point elevation, freezing-point depression, osmotic pressure, vapor-pressure lowering.
- What is electronegativity trend?
- Increases up and to the right of the periodic table; fluorine is most electronegative.
- Atomic radius trend?
- Increases down a group and to the left across a period (more shells, less effective nuclear pull).
- Ionization energy trend?
- Increases up and to the right — it's hardest to remove an electron from a small, electron-greedy atom.
- Ionic vs covalent bond?
- Ionic = electron transfer between metal and nonmetal (large ΔEN); covalent = electron sharing between nonmetals.
- Polar vs nonpolar covalent bond?
- Polar has unequal electron sharing (moderate ΔEN, a dipole); nonpolar shares electrons equally (ΔEN ≈ 0).
- VSEPR — shape of 4 bonding pairs?
- Tetrahedral, 109.5° bond angles (e.g., CH₄). Lone pairs compress these angles.
- Hybridization sp, sp², sp³?
- sp = linear (2 groups), sp² = trigonal planar (3 groups), sp³ = tetrahedral (4 groups).
- Three intermolecular forces, strongest first?
- Hydrogen bonding > dipole-dipole > London dispersion forces. All are weaker than covalent bonds.
- Quantum numbers — what does n give?
- The principal quantum number n gives the energy level/shell and relative size of an orbital.
- Hund's rule?
- Electrons fill degenerate orbitals singly with parallel spins before pairing up.
- Pauli exclusion principle?
- No two electrons in an atom can have the same four quantum numbers; an orbital holds at most 2 (opposite spins).
- Heisenberg uncertainty principle?
- You cannot simultaneously know an electron's exact position and momentum.
- What is half-life?
- The time for half of a sample to decay or react; for first-order processes it is constant (t½ = 0.693/k).
- Rate law form?
- rate = k[A]ᵐ[B]ⁿ. The exponents (orders) are found experimentally, not from coefficients.
- Effect of temperature on reaction rate?
- Higher temperature increases rate by giving more molecules energy ≥ the activation energy (Arrhenius).
- What is activation energy?
- The minimum energy needed to start a reaction; catalysts lower it by providing an alternate pathway.
- Solubility product Ksp — meaning?
- The equilibrium constant for a slightly soluble salt dissolving; higher Ksp means greater solubility.
- Common-ion effect?
- Adding an ion already in a salt's equilibrium decreases its solubility (Le Chatelier shift).
- Percent yield formula?
- Percent yield = (actual yield / theoretical yield) × 100%.
- SN1 best substrate and stereochemistry?
- Tertiary (3°) carbons via a carbocation; gives racemization. Favored by polar protic solvents and weak nucleophiles.
- SN2 best substrate and stereochemistry?
- Primary (1°)/methyl carbons; concerted backside attack inverts configuration. Needs a strong nucleophile and polar aprotic solvent.
- E1 vs E2 elimination?
- E1 is stepwise via a carbocation (first-order); E2 is concerted, needs a strong base, and is anti-periplanar (second-order).
- Markovnikov's rule?
- In electrophilic addition to an alkene, H adds to the carbon with more H's, forming the more stable carbocation.
- What is a chiral center?
- A carbon bonded to four different groups; it makes the molecule non-superimposable on its mirror image.
- Enantiomers vs diastereomers?
- Enantiomers are mirror images (all stereocenters differ); diastereomers differ at some but not all stereocenters.
- What are enantiomers' properties?
- Identical physical properties except they rotate plane-polarized light in opposite directions (optical activity).
- R vs S configuration — how assigned?
- Rank substituents by Cahn-Ingold-Prelog priority; lowest points away. Clockwise = R, counterclockwise = S.
- What is a racemic mixture?
- A 50:50 mix of two enantiomers; it is optically inactive because the rotations cancel.
- Functional group: carboxylic acid?
- −COOH. Acidic; named with '-oic acid.' Found in fatty acids and amino acids.
- Functional group: aldehyde vs ketone?
- Aldehyde has a carbonyl at a chain end (−CHO, '-al'); ketone has it internal (R-CO-R, '-one').
- Functional group: ester vs amide?
- Ester (R-CO-O-R) smells fruity; amide (R-CO-N) has the peptide-bond linkage and is more stable.
- Functional group priority for naming (high)?
- Carboxylic acid > ester > amide > aldehyde > ketone > alcohol > amine — highest gets the suffix.
- What is aromaticity (Hückel's rule)?
- A cyclic, planar, fully conjugated ring with 4n+2 π electrons (e.g., benzene with 6) is unusually stable.
- Benzene's characteristic reaction?
- Electrophilic aromatic substitution (EAS) — it substitutes rather than adds, preserving aromaticity.
- Oxidation of a primary alcohol gives?
- An aldehyde, then (with a strong oxidant) a carboxylic acid. Secondary alcohols give ketones.
- What is a nucleophile vs electrophile?
- A nucleophile is electron-rich and donates an electron pair; an electrophile is electron-poor and accepts one.
- What does IR spectroscopy identify?
- Functional groups by bond vibrations — e.g., a broad ~3300 cm⁻¹ O-H, a sharp ~1700 cm⁻¹ C=O.
- Key IR peak: carbonyl (C=O)?
- A strong, sharp absorption near 1700 cm⁻¹ — diagnostic of aldehydes, ketones, acids, esters.
- Key IR peak: O-H of an alcohol?
- A broad absorption around 3200–3550 cm⁻¹.
- What does ¹H NMR tell you?
- The number, environment, and neighbors of hydrogens — via chemical shift, integration, and splitting (n+1 rule).
- NMR splitting (n+1 rule)?
- A proton with n equivalent neighboring protons splits into n+1 peaks.
- Downfield NMR shift means?
- A more deshielded proton (near electronegative atoms or π systems), appearing at higher ppm.
- What is a constitutional (structural) isomer?
- Molecules with the same formula but different connectivity (e.g., butane vs isobutane).
- Cis vs trans (geometric isomers)?
- Cis = same side of a double bond/ring; trans = opposite sides. They have different properties.
- Keto-enol tautomerism?
- A rapid equilibrium between a keto form (C=O) and an enol form (C=C-OH); the keto form usually dominates.
- What is resonance?
- Delocalization of electrons across multiple structures; the true molecule is a stabilized hybrid.
- What is a Grignard reagent?
- An organomagnesium (R-MgX) that acts as a strong nucleophile/base, adding R to carbonyls to form alcohols.
- Aldol condensation?
- An enolate attacks another carbonyl to form a β-hydroxy carbonyl, which can dehydrate to an α,β-unsaturated product.
- Esterification (Fischer)?
- A carboxylic acid + alcohol, acid-catalyzed, form an ester plus water (reversible).
- Saponification?
- Base hydrolysis of an ester (or fat) into a carboxylate salt (soap) and an alcohol.
- What is a carbocation stability order?
- 3° > 2° > 1° > methyl — more alkyl groups donate electron density and hyperconjugation.
- Polar protic vs aprotic solvent?
- Protic (water, alcohols) H-bond to nucleophiles and favor SN1/E1; aprotic (acetone, DMSO) favor SN2.
- What is a leaving group?
- A group that departs with the bonding electrons; good ones are stable/weak bases (e.g., I⁻, Br⁻, tosylate).
- Conjugation — why does it matter?
- Alternating single/double bonds delocalize electrons, lowering energy and shifting UV/Vis absorption.
- What is hydrogenation?
- Addition of H₂ across a C=C (often with a Pt/Pd/Ni catalyst), reducing an alkene to an alkane.
- Electrophilic addition to alkene with HBr?
- H and Br add across the double bond following Markovnikov's rule (H to the more-substituted carbon's neighbor).
- Distinguish primary, secondary, tertiary carbon?
- By how many other carbons it's bonded to: 1° (one), 2° (two), 3° (three).
- What is a stereospecific reaction?
- One in which the stereochemistry of the reactant determines the stereochemistry of the product (e.g., SN2).
- Newton's first law?
- An object stays at rest or in uniform motion unless acted on by a net external force (inertia).
- Newton's third law?
- For every action there is an equal and opposite reaction force on the other object.
- Kinematics: velocity vs acceleration?
- Velocity is the rate of change of position (m/s); acceleration is the rate of change of velocity (m/s²).
- Equation v = v₀ + at — what is it?
- Final velocity from initial velocity, acceleration, and time (constant acceleration).
- Equation Δx = v₀t + ½at²?
- Displacement under constant acceleration from initial velocity, time, and acceleration.
- Projectile motion key idea?
- Horizontal and vertical motions are independent; horizontal velocity is constant, vertical accelerates at g.
- Value of g near Earth's surface?
- About 9.8 m/s² downward (acceleration due to gravity).
- Work formula?
- W = Fd·cosθ — force times displacement times the cosine of the angle between them. Unit: joule.
- Kinetic energy formula?
- KE = ½mv². Doubling speed quadruples kinetic energy.
- Gravitational potential energy?
- PE = mgh — mass times g times height above a reference point.
- Conservation of mechanical energy?
- Without friction, KE + PE is constant; energy converts between forms but the total stays the same.
- Power formula?
- P = W/t = Fv. Unit: watt (W = J/s). Power is the rate of doing work.
- Momentum formula?
- p = mv — mass times velocity (a vector). Conserved in the absence of external forces.
- Impulse-momentum theorem?
- Impulse = FΔt = Δp. A force over time changes momentum.
- Elastic vs inelastic collision?
- Both conserve momentum; elastic also conserves kinetic energy, inelastic does not (objects may stick).
- Centripetal acceleration?
- a = v²/r, directed toward the center; it keeps an object in circular motion.
- Hooke's law?
- F = −kx — a spring's restoring force is proportional to its displacement from equilibrium.
- Period of a simple pendulum?
- T = 2π√(L/g) — depends on length and gravity, not on mass or (small) amplitude.
- Density formula?
- ρ = m/V (mass per volume). Water is ~1000 kg/m³ (1 g/cm³).
- Pressure formula?
- P = F/A — force per unit area. Unit: pascal (Pa = N/m²).
- Pascal's principle?
- Pressure applied to a confined fluid is transmitted equally throughout (basis of hydraulics).
- Archimedes' principle (buoyancy)?
- The buoyant force equals the weight of fluid displaced; an object floats if it's less dense than the fluid.
- Bernoulli's principle?
- In flowing fluid, faster speed means lower pressure (energy conservation along a streamline).
- Continuity equation for fluids?
- A₁v₁ = A₂v₂ — a narrower pipe makes incompressible fluid flow faster (flow rate is constant).
- Ohm's law?
- V = IR — voltage equals current times resistance.
- Electrical power formula?
- P = IV = I²R = V²/R. Unit: watt.
- Resistors in series vs parallel?
- Series add directly (R = R₁+R₂); parallel add as reciprocals (1/R = 1/R₁+1/R₂), giving less total resistance.
- Capacitors in series vs parallel?
- Opposite of resistors: parallel add directly; series add as reciprocals.
- Coulomb's law?
- F = kq₁q₂/r² — the electrostatic force between charges; like charges repel, opposite attract.
- Electric field of a point charge?
- E = kq/r², pointing away from positive and toward negative charge. Unit: N/C or V/m.
- Wave speed equation?
- v = fλ — speed equals frequency times wavelength.
- Frequency vs period relationship?
- f = 1/T. Frequency is cycles per second (Hz); period is seconds per cycle.
- Transverse vs longitudinal wave?
- Transverse oscillates perpendicular to travel (light); longitudinal oscillates parallel (sound).
- Constructive vs destructive interference?
- In-phase waves add (constructive); out-of-phase waves cancel (destructive).
- Doppler effect?
- Observed frequency rises as a source approaches and falls as it recedes (a shift in perceived pitch).
- Speed of sound vs light?
- Sound ≈ 343 m/s in air; light ≈ 3×10⁸ m/s in vacuum. Light needs no medium.
- Snell's law (refraction)?
- n₁sinθ₁ = n₂sinθ₂ — light bends toward the normal entering a denser (higher-n) medium.
- Index of refraction?
- n = c/v — how much a medium slows light. Higher n means slower light and more bending.
- Total internal reflection?
- Above a critical angle, light hitting a less-dense medium reflects entirely (basis of fiber optics).
- Converging vs diverging lens?
- Converging (convex) focuses light to a real image; diverging (concave) spreads it, making a virtual image.
- Thin lens / mirror equation?
- 1/f = 1/do + 1/di — relates focal length to object and image distances.
- What is magnification?
- m = −di/do = hi/ho. Negative m means an inverted image; |m|>1 means enlarged.
- Heat transfer methods?
- Conduction (contact), convection (fluid motion), and radiation (electromagnetic waves).
- Specific heat — meaning?
- The heat to raise 1 g of a substance by 1°C (Q = mcΔT). Water's high value resists temperature change.
- What is the photoelectric effect?
- Light above a threshold frequency ejects electrons from a metal — evidence that light is quantized (photons).
- Energy of a photon?
- E = hf = hc/λ — proportional to frequency; h is Planck's constant.
- Half-life in radioactive decay?
- The time for half of a radioactive sample to decay; constant for a given isotope.
- Alpha vs beta vs gamma radiation?
- Alpha = He nucleus (least penetrating); beta = electron/positron; gamma = high-energy photon (most penetrating).
- Decibel scale — what kind of scale?
- Logarithmic; every +10 dB is a tenfold increase in sound intensity.
- Operant conditioning?
- Learning in which behavior is shaped by its consequences — reinforcement increases it, punishment decreases it (Skinner).
- Positive vs negative reinforcement?
- Positive adds a pleasant stimulus; negative removes an unpleasant one. Both increase behavior.
- Reinforcement vs punishment?
- Reinforcement increases a behavior; punishment decreases it. Each can be positive (add) or negative (remove).
- Most resistant reinforcement schedule?
- Variable-ratio (unpredictable number of responses) — it produces high, steady, extinction-resistant responding.
- Three stages of memory?
- Sensory memory → short-term/working memory → long-term memory (via encoding and consolidation).
- Explicit vs implicit memory?
- Explicit (declarative) is conscious facts/events; implicit (procedural) is skills and conditioned responses.
- What is the serial position effect?
- Better recall of the first (primacy) and last (recency) items in a list than the middle.
- Piaget's four stages?
- Sensorimotor, preoperational, concrete operational, formal operational — cognitive development from infancy to adolescence.
- Piaget — object permanence?
- Knowing objects exist when out of sight; it develops in the sensorimotor stage.
- Erikson's psychosocial conflict in adolescence?
- Identity vs role confusion — adolescents work to form a coherent sense of self.
- Kohlberg's three levels of moral development?
- Preconventional (punishment/reward), conventional (social rules), postconventional (abstract principles).
- Parts of Freud's structural model?
- Id (desires), ego (reality), superego (morality). The ego mediates between the id and superego.
- Sympathetic nervous system role?
- The 'fight or flight' response — raises heart rate, dilates pupils, releases epinephrine.
- Maslow's hierarchy of needs (order)?
- Physiological → safety → love/belonging → esteem → self-actualization.
- Neurotransmitter: dopamine?
- Linked to reward, motivation, and movement; implicated in Parkinson's (low) and schizophrenia (excess activity).
- Neurotransmitter: serotonin?
- Regulates mood, sleep, and appetite; low levels are associated with depression.
- Neurotransmitter: GABA?
- The main inhibitory neurotransmitter — it reduces neuronal excitability and calms the brain.
- Function of the amygdala?
- Processes emotion, especially fear and the response to threatening stimuli.
- Function of the hippocampus?
- Forms new long-term (declarative) memories and supports spatial navigation.
- Function of the prefrontal cortex?
- Executive functions — planning, decision-making, impulse control, and personality.
- Broca's vs Wernicke's area?
- Broca's (frontal) = speech production; Wernicke's (temporal) = language comprehension.
- James-Lange vs Cannon-Bard theory of emotion?
- James-Lange: bodily arousal causes emotion. Cannon-Bard: arousal and emotion occur simultaneously.
- Schachter-Singer two-factor theory?
- Emotion = physiological arousal + a cognitive label of that arousal based on context.
- Absolute vs difference threshold?
- Absolute = minimum stimulus detectable 50% of the time; difference (JND) = smallest detectable change.
- Weber's law?
- The just-noticeable difference is a constant proportion of the original stimulus, not a fixed amount.
- What is signal detection theory?
- How we detect stimuli amid noise, influenced by both sensitivity and response bias (hits, misses, false alarms).
- Top-down vs bottom-up processing?
- Top-down uses prior knowledge/expectations; bottom-up builds perception from raw sensory data.
- What is a stereotype, prejudice, and discrimination?
- Stereotype = belief; prejudice = attitude/feeling; discrimination = behavior. Cognition, affect, action.
- Fundamental attribution error?
- Overattributing others' behavior to their character and underweighting situational causes.
- Cognitive dissonance?
- Discomfort from holding conflicting beliefs/actions, motivating attitude change to reduce it (Festinger).
- What is the mere-exposure effect?
- Repeated exposure to a stimulus increases liking for it.
- Stages of sleep — where do dreams mainly occur?
- REM sleep — marked by rapid eye movement, vivid dreams, and muscle atonia.
- What are circadian rhythms?
- ~24-hour biological cycles (e.g., sleep-wake) regulated by the suprachiasmatic nucleus and influenced by light/melatonin.
- Heuristic vs algorithm?
- A heuristic is a fast mental shortcut (sometimes biased); an algorithm is a step-by-step method guaranteeing a solution.
- Availability vs representativeness heuristic?
- Availability judges by how easily examples come to mind; representativeness judges by similarity to a prototype.
- Type vs trait theories of personality?
- Type theories sort people into categories; trait theories rate continuous dimensions (e.g., the Big Five).
- The Big Five personality traits (OCEAN)?
- Openness, Conscientiousness, Extraversion, Agreeableness, Neuroticism.
- Positive vs negative symptoms of schizophrenia?
- Positive add experiences (hallucinations, delusions); negative subtract (flat affect, avolition).
- Classical conditioning terms (UCS/UCR/CS/CR)?
- UCS triggers a natural UCR; after pairing, a CS triggers a learned CR (e.g., bell → salivation).
- What is observational learning?
- Learning by watching and imitating others (Bandura's social learning; the Bobo doll study).
- Sensation vs perception?
- Sensation is detecting raw stimuli; perception is the brain's organization and interpretation of them.
- What is the spacing effect?
- Information is retained better when study is spread over time rather than massed (crammed).
- Drive-reduction theory?
- Behavior is motivated to reduce internal tension from unmet biological needs, restoring homeostasis.
- What is the Yerkes-Dodson law?
- Performance peaks at moderate arousal; too little or too much arousal impairs it (an inverted U).
- Three major sociological paradigms?
- Functionalism, conflict theory, and symbolic interactionism.
- Functionalism — core idea?
- Society is a system of interdependent parts that work together to maintain stability (Durkheim).
- Conflict theory — core idea?
- Society is shaped by competition over scarce resources and power, producing inequality (Marx).
- Symbolic interactionism — core idea?
- Society emerges from everyday interactions and shared meanings/symbols (micro-level; Mead, Goffman).
- Marx — bourgeoisie vs proletariat?
- The bourgeoisie own the means of production; the proletariat sell their labor. Class conflict drives change.
- Weber's contribution?
- Emphasized rationalization, bureaucracy, and the role of ideas (the Protestant ethic) in social life.
- What is socialization?
- The lifelong process of learning a society's norms, values, and roles (family is the primary agent).
- Primary vs secondary group?
- Primary groups are small and intimate (family, close friends); secondary groups are larger and goal-oriented.
- What is a social institution?
- An enduring structure meeting basic needs — e.g., family, education, religion, government, the economy.
- Ascribed vs achieved status?
- Ascribed status is assigned at birth (e.g., race); achieved status is earned through actions (e.g., a profession).
- What is a role conflict vs role strain?
- Role conflict is tension between different roles; role strain is tension within a single role.
- Social stratification?
- A society's hierarchical ranking of people into layers based on wealth, power, and prestige.
- Caste vs class system?
- Caste is closed and ascribed (little mobility); class is more open and allows social mobility.
- What is social mobility?
- Movement between social positions — intergenerational (across generations) or intragenerational (within a lifetime).
- Absolute vs relative poverty?
- Absolute poverty is lacking basic necessities; relative poverty is being poor compared to others in society.
- What is cultural capital?
- Non-financial assets (education, tastes, skills) that confer social advantage (Bourdieu).
- Meritocracy?
- A system in which rewards are based on individual talent and effort rather than inherited status.
- What is the demographic transition?
- A shift from high birth/death rates to low ones as a society industrializes, changing population growth.
- Push vs pull factors in migration?
- Push factors drive people from an area (war, famine); pull factors attract them to another (jobs, safety).
- What is urbanization?
- The growing concentration of population in cities, often tied to industrialization.
- Gemeinschaft vs Gesellschaft?
- Gemeinschaft = close, traditional community ties; Gesellschaft = impersonal, modern, goal-driven relationships (Tönnies).
- What is anomie?
- A state of normlessness where social norms weaken or conflict, often during rapid change (Durkheim).
- Labeling theory?
- Deviance arises because society labels acts (or people) as deviant, which can become a self-fulfilling identity.
- What is the McDonaldization of society?
- Ritzer's idea that the fast-food model's efficiency, calculability, predictability, and control spread through institutions.
- What is the self-fulfilling prophecy?
- A belief or expectation that causes its own fulfillment through people's behavior.
- In-group vs out-group?
- An in-group is one a person identifies with; an out-group is one seen as 'other,' often with bias.
- What are social control mechanisms?
- Formal (laws, sanctions) and informal (norms, peer pressure) means a society uses to enforce conformity.
- Globalization?
- The increasing interconnection of economies, cultures, and populations across national borders.
- What is healthcare disparity?
- Differences in health outcomes and access across social groups, often tied to socioeconomic status and race.
- What does CARS test?
- Critical Analysis and Reasoning Skills — reading comprehension and reasoning, with no outside science knowledge required.
- CARS — three skill categories?
- Foundations of Comprehension, Reasoning Within the Text, and Reasoning Beyond the Text.
- CARS format?
- 53 questions on 9 passages in 90 minutes, drawn from the humanities and social sciences.
- CARS — 'main idea' question strategy?
- Pick the choice that captures the whole passage's central argument, not just one supporting detail.
- CARS — how to handle inference questions?
- Choose the conclusion the passage logically supports; reject answers that add unstated facts or overreach.
- CARS — biggest trap?
- Bringing in outside knowledge or opinion. Every correct answer must be grounded in the passage itself.
- CARS — 'strengthen/weaken' question approach?
- Find the answer that most directly supports or undermines the author's specific argument as stated.
- CARS — author's tone, how to gauge?
- Use word choice and connotation; watch for hedging, criticism, or endorsement signaled by the language.
- CARS — 'EXCEPT/NOT' questions?
- The correct answer is the one that is false or unsupported; three choices will be true per the passage.
- CARS — application questions?
- Apply the passage's principle to a new scenario; pick the option most consistent with the author's logic.
- CARS — best pacing strategy?
- About 10 minutes per passage; don't over-invest in one. Answer every question — there's no guessing penalty.