This free HESI A2 study guide walks through every section the Elsevier (Admission Assessment) tests for nursing and allied-health admissions — Mathematics, Reading, Vocabulary, Grammar, Anatomy & Physiology, Biology, Chemistry, and (for some programs) Physics.[2]
The single most important thing to know first: the HESI A2 is a . Each program chooses which sections you take (commonly four to six) and sets its own passing score— so there is no single national form, length, or pass mark. Confirm your program’s required sections and cutoff before you study.[3]
It’s interactive, not a wall of text: every section has high-yield notes, worked scenarios, labeled diagrams, flashcards, and practice questions, so you learn by doing — not just reading. Drill gaps with our free practice test and flashcards.
HESI A2 Exam Snapshot
Because the HESI A2 is school-configured, the counts and times below are typical ranges, not a single official blueprint. Each scored section also carries about five unscored , so the administered count exceeds the scored count.[4][5]
| Section | Scored Qs (typical) | Time (typical) | How common |
|---|---|---|---|
| Mathematics | ~50 | ~50 min | Core — almost always required |
| Reading Comprehension | ~47–55 | ~60 min | Core — almost always required |
| Vocabulary & General Knowledge | ~50 | ~50 min | Core — almost always required |
| Grammar | ~50 | ~50 min | Core — almost always required |
| Anatomy & Physiology | ~25–30 | ~25 min | Most common science |
| Biology | ~25–30 | ~25 min | School-dependent |
| Chemistry | ~25–30 | ~25 min | Uncommon |
| Physics | ~25 | ~25–50 min | Rare (physics prerequisite only) |
A common four-section exam (Math, Reading, Vocabulary, Grammar) runs roughly 200 scored questions in about 210 minutes; adding sciences raises the total. There is no universal passing score — programs commonly require around 75–80%, and many gate on each section individually. Two non-scored modules (Learning Style and Personality Profile) are diagnostic only and never affect your academic score.[4]
Mathematics
Mathematics is a near-universal core section — about 50 scored questions in roughly 50 minutes. It is applied arithmetic for nursing, not algebra: the exam rewards fast, accurate fraction, decimal, and percent work, , and memorized conversions. By community report, roughly 30 of 50 questions are / or conversion based.[12]
Two facts shape your whole strategy: there is no formula or conversion sheet, and many testing centers provide no calculator — so equivalents must be memorized cold. Read each question carefully to decide whether to multiply or divide; that direction error is a top failure mode.[5]
How the Math section is built (read this first)
Spend your hours where the points are. Ratios, proportions, and unit conversions dominate, followed by fraction/decimal/percent fluency and a few nursing-flavored dosage problems. Roman numerals, military time, and basic algebra are lower-frequency “sleepers” worth a quick review.[1]
Follow on every multi-step problem: Parentheses, Exponents, Multiplication/Division (left to right), then Addition/Subtraction. The most-missed order-of-operations error is doing addition before multiplication — , not 20.[12]
| Topic | Frequency | What to drill |
|---|---|---|
| Ratios, proportions & conversions | Highest (~30 of 50) | Cross-multiplication, metric & household equivalents |
| Fractions, decimals & percents | High | Convert in every direction; simplify answers |
| Dosage calculations | Medium (2–3 items) | Dose ordered dose on hand quantity |
| Roman numerals, military time, algebra | Low (sleepers) | Quick review for easy points |
Fractions, decimals, and percents
Convert fluently in every direction. A fraction becomes a decimal by dividing top by bottom; a decimal becomes a percent by multiplying by 100; a percent becomes a fraction over 100, then reduce. The single most common careless error is not simplifying the final answer — answer choices are usually in lowest terms.[12]
To add or subtract fractions, find a common denominator first (); to multiply, go straight across and simplify; to divide, multiply by the reciprocal ().[12]
For percents, anchor on one relationship: . The classic HESI “12 of 50” score pattern is just . is a separate formula: .[12]
| Fraction | Decimal | Percent |
|---|---|---|
| 0.25 | 25% | |
| 0.333… | 33.3% | |
| 0.5 | 50% | |
| 0.667… | 66.7% | |
| 0.75 | 75% | |
| 0.8 | 80% |
Ratios, proportions, and dosage — the highest-yield topic
A sets two ratios equal; solve by : . Keep matching units in matching positions (mg over mL on both sides) — a mismatched setup is the top failure mode.[12]
Treat dosage problems as proportions. The core is — and always convert to a common unit before computing.[13]
- 1
Step 1
Convert both quantities to the same unit (e.g., g → mg)
- 2
Step 2
Set up two ratios with matching units in the same positions:
- 3
Step 3
Cross-multiply:
- 4
Step 4
Divide to isolate , then check the answer is reasonable
Measurement and unit conversions (memorize cold)
No reference sheet is provided, so the equivalents must be automatic. Use the metric ladder for metric-to-metric moves, and memorize the household and metric↔household equivalents below. One HESI convention to note: on the HESI (not the ~64.8 mg pure value).[12]
The metric ladder — “King Henry Died By Drinking Chocolate Milk”
Each rung is a factor of 10. Moving DOWN the ladder (kg → g → mg), move the decimal RIGHT and multiply; moving UP, move the decimal LEFT and divide. Example: 2 kg = 2000 g.
| Category | Equivalents |
|---|---|
| Metric | 1 kg = 1000 g · 1 g = 1000 mg · 1 mg = 1000 mcg · 1 L = 1000 mL · 1 cc = 1 mL |
| Metric ↔ household | 1 kg = 2.2 lb · 1 in = 2.54 cm · 1 tsp = 5 mL · 1 tbsp = 15 mL · 1 fl oz = 30 mL · 1 cup = 240 mL |
| Household chain | 3 tsp = 1 tbsp · 2 tbsp = 1 oz · 2 cups = 1 pint · 2 pints = 1 qt · 4 qt = 1 gal |
| HESI special | 1 grain = 60 mg (HESI value) · 1 lb = 16 oz |
| Temperature | · |
Roman numerals, military time, and basic algebra
Roman numerals: I=1, V=5, X=10, L=50, C=100, D=500, M=1000; a smaller symbol before a larger one subtracts (IV=4, IX=9, XL=40, XC=90, CM=900), so XCVI = 96. Military (24-hour) time adds 1200 to PM hours — 1 p.m. = 1300, 11 p.m. = 2300, and midnight = 0000.[1]
Basic algebra is light: solve for the variable with inverse operations, e.g. .[12]
Checkpoint · Mathematics
Question 1 of 10
What is 35% of 10.25? Round to the nearest hundredth.
Reading Comprehension
Reading is a near-universal core section — about 47–55 scored questions in roughly 60 minutes. Passages are short-to-medium and often health, science, or general-interest. The dominant skill is disciplined reading: every answer must be supported by the passage, so using outside knowledge is the single biggest trap.[14]
Main idea, supporting details, and inference
Separate three things questions deliberately blur. The is the single point the whole passage supports; a is a stated fact that backs it; and an is a conclusion the passage logically supports but does not state. The classic trap is a true detail dressed up as the main idea.[14]
The main idea is often stated in the first or last sentence of a paragraph. For detail questions (“according to the passage…”), locate the exact sentence by scanning for keywords. For inference, stay one small stepfrom the text — reject any choice that adds outside facts, even if it “could be true in real life.”[14]
| Term | Scope | Example (passage on hydration) |
|---|---|---|
| Topic | 1–2 words | Hydration |
| Main idea | Whole passage | Nurses must monitor fluid balance closely |
| Supporting detail | One fact | Dark urine can signal dehydration |
Author's purpose, tone, and text structure
Identify the : to inform, persuade, entertain, describe, or instruct. Most informational and health passages are written to inform, so beware reading them as persuasive. is the author's attitude, judged from word choice (connotation) — most health passages are neutral and objective.[14]
Recognize organization from signal words: because/therefore (cause–effect), however/unlike (contrast), first/next/finally (sequence), for example (illustration). Separate (verifiable) from (a judgment, often marked by best, should, or unfortunately).[14]
Reading strategy and common traps
Read the question first, then scan the passage for the relevant spot — efficient with roughly a minute per question. Eliminate choices that are too broad, too narrow, not stated, or contradicted. For “EXCEPT/NOT” questions, find the three that ARE supported; the odd one out is the answer.[14]
| Trap | Why it fools you | Defense |
|---|---|---|
| Detail posing as main idea | The detail is true | Pick the choice covering the whole passage |
| Over-inferring | It sounds reasonable | Reject any added fact not in the text |
| Using outside knowledge | You already know it | Answer only from the passage |
| Extreme language | Sounds decisive | Distrust always/never unless the text is equally absolute |
Checkpoint · Reading Comprehension
Question 1 of 10
A team led by Massachusetts General Hospital produced premature cells that support early heart development. These scientists hope to use patient cells to generate functioning heart tissue. If they are successful, the cells could revolutionize transplants in treating heart failure. Pre-epicardial cells form the epicardium, a membrane covering the heart’s outer surface. These cells are central in supporting heart development in utero. Mature cells from the skin, for instance, can be reprogrammed into embryo-like stem cells. When heart muscle cells contact pre-epicardial cells, they develop into vital epicardial cells to support embryonic heart formation. A single blood draw can help retrace early heart development stages, but the more advanced heart structure is highly complex. The findings may eventually contribute to new heart failure therapies. What is the best summary of the passage?
Vocabulary & General Knowledge
Vocabulary is a near-universal core section — about 50 scored questions in roughly 50 minutes. It tests academic and medical/health-contextvocabulary, frequently framed in a clinical sentence (“The patient was admitted for an acutecough”). It is often called the easiest section to study for, yet it is a sleeper failure section because the official review book omits many commonly tested everyday words.[17]
High-yield medical vocabulary
Because the framing is clinical, the same word carries its medical sense. Know the high-frequency clinical words such as vs. , vs. , vs. , and .[17]
| Word | Meaning |
|---|---|
| Acute | Sudden onset, short and severe (opposite: chronic) |
| Patent | Open, unobstructed (a patent airway) |
| Occluded | Blocked, closed off |
| Edema | Swelling caused by fluid |
| Distended | Swollen, stretched out |
| Contraindication | A reason NOT to use a treatment |
| Prognosis | The likely outcome of a condition |
| Etiology | The cause of a disease |
| Adverse | Harmful, unfavorable (an adverse reaction) |
Academic vocabulary and word parts
Many tested words are everyday academic English — abate, abstain, ambiguous, candid, discrepancy, exacerbate, prudent, virulent. When a word is unfamiliar, decode it with word parts: a changes meaning at the front, a carries the core meaning, and a often marks a condition.[17]
| Word part | Type | Meaning | Example |
|---|---|---|---|
| hyper- | prefix | excessive / above | hypertension |
| hypo- | prefix | deficient / below | hypothermia |
| a- / an- | prefix | without | anemia |
| tachy- | prefix | fast | tachycardia |
| brady- | prefix | slow | bradycardia |
| -itis | suffix | inflammation | arthritis |
| -ectomy | suffix | surgical removal | appendectomy |
| -ology | suffix | study of | cardiology |
Context-clue and elimination strategy
Use in the sentence: a definition clue restates the meaning, a contrast clue (“but/unlike”) signals the opposite, and an example clue illustrates it. Read the sentence’s charge (positive or negative) and pick a matching-charge answer.[14]
- 1
Step 1
Read the whole clinical sentence for context
- 2
Step 2
Split the word into prefix, root, and suffix
- 3
Step 3
Use any context clue — definition, contrast, or example
- 4
Step 4
Judge the sentence's charge (positive/negative) and match it
- 5
Step 5
Eliminate the two clearly wrong options, then decide
Checkpoint · Vocabulary & General Knowledge
Question 1 of 10
What word has a similar meaning to “cheap; tasteless”?
Grammar
Grammar is a near-universal core section — about 50 scored questions in roughly 50 minutes. The format is heavily “find the error” and best-usage: pick the correct option or the word that fixes a sentence. It tests standard formal written English, not casual speech.[15]
Agreement and parts of speech
Know the parts of speech (noun, pronoun, verb, adjective, adverb, preposition, conjunction) and that an adverb modifies a verb (“She did well,” not “good”). is tested on nearly every form: ignore words between the subject and verb (“The box of supplies ishere”), and treat indefinite pronouns (each, every, everyone, neither) as singular.[15]
For pronoun case, use subject pronouns (I, he, she, we, they) as subjects and object pronouns (me, him, her, us, them) as objects — “between you and me,” never “I.” Use who for subjects and whom for objects.[15]
Sentence structure and punctuation
A is missing a subject or verb (“Because she studied.”); a or wrongly joins two independent clauses (“She studied, she passed.”) — fix with a period, semicolon, or a conjunction. Keep items in a list parallel (“reading, writing, and studying”).[15]
Use the apostrophe for possession (nurse’s) and contractions (don’t), never for plain plurals; a semicolon joins two related independent clauses. Capitalize sentence starts and proper nouns.[15]
| Error | Example | Fix |
|---|---|---|
| Fragment | Because she studied. | Add an independent clause: '…she studied, she passed.' |
| Comma splice | The patient was stable, the nurse charted. | Period, semicolon, or add a conjunction (so) |
| Subject-verb | The box of tools are heavy. | Subject is 'box' (singular) → 'is' |
| Apostrophe | The nurse's chart vs. the nurses' break room | Singular vs. plural possession; never for plain plurals |
Commonly confused words
High-yield and confusables recur on nearly every form: (verb) vs. (noun), their/there/they’re, your/you’re, its/it’s, than/then, accept/except, principal/principle, and fewer/less.[16]
| Pair | Word 1 | Word 2 |
|---|---|---|
| affect / effect | affect = verb (to influence) | effect = noun (a result) |
| its / it's | its = possessive | it's = it is |
| than / then | than = comparison | then = time/sequence |
| accept / except | accept = receive | except = exclude |
| fewer / less | fewer = countable items | less = uncountable amount |
Checkpoint · Grammar
Question 1 of 10
Choose the correct word for the blank in the following sentence: One would expect Jamie, the analyst, to know _______ about his own job.
Anatomy & Physiology
Anatomy & Physiology is the most commonly added science (about 25–30 questions, ~25 minutes) and the single most-feared section because of its breadth and applied physiology. The #1 community warning: the official review book’s A&P chapter does not fully prepare you — study broad system function and cause-and-effect, not just definitions. Highest-yield clusters are cardiac blood flow, the endocrine gland→hormone map, and directional terms.[7]
Directional terms, planes, and tissues
Know directional terms (/, /, /, superior/inferior) and the three body planes: (left/right), (front/back), and (top/bottom). The levels of organization run chemical → cell → tissue → organ → organ system → organism, and the four tissue types are epithelial, connective, muscle, and nervous.[7]
Cardiovascular system and blood flow (highest-yield)
The heart appears on virtually every form, so know it cold. It has four chambers — right and left atria (receive) and right and left ventricles (pump). The is the strongest because it pumps to the whole body. Valves: (right, 3 cusps) and (left, 2 cusps) — mnemonic LAB RAT (Left=Bicuspid, Right=Tricuspid).[6]
Trace the blood-flow path: body → right atrium → → right ventricle → pulmonary valve → → lungs → → left atrium → → → aortic valve → → body. The pulmonary artery (deoxygenated) and pulmonary vein (oxygenated) are the two famous exceptions to the arteries-carry-oxygen rule.[6]
- 1
Step 1
Body (deoxygenated) → right atrium via the vena cava
- 2
Step 2
Tricuspid valve → right ventricle
- 3
Step 3
Pulmonary valve → pulmonary artery → lungs (gas exchange)
- 4
Step 4
Pulmonary veins → left atrium (now oxygenated)
- 5
Step 5
Mitral (bicuspid) valve → left ventricle
- 6
Step 6
Aortic valve → aorta → out to the body
Right side · deoxygenated blood
- Right atrium — receives oxygen-poor blood from the body via the vena cava
- ↓ through the tricuspid valve (3 cusps — “R” in LAB RAT)
- Right ventricle — pumps blood toward the lungs
- ↓ pulmonary valve → pulmonary artery (the one artery carrying deoxygenated blood) → lungs
Left side · oxygenated blood
- Left atrium — receives oxygen-rich blood from the pulmonary veins (the only veins carrying oxygenated blood)
- ↓ through the bicuspid / mitral valve (2 cusps — “L” in LAB RAT)
- Left ventricle — the largest, strongest chamber
- ↓ through the aortic valve → the aorta → out to the whole body
Pattern to memorize: Vein → Atrium → Valve → Ventricle → Valve → Artery. Arteries carry blood AWAY from the heart; veins carry it TOWARD the heart. LAB RAT = Left-Bicuspid, Right-Tricuspid.
Endocrine glands and hormones (high-yield)
The system is a frequent trap because students confuse which gland makes which hormone. The is the “master gland”; the(PTH) raises blood calcium when it drops, while the thyroid’s calcitonin lowers it; and the pancreas releases (lowers blood sugar) and (raises it).[8]
| Gland | Hormone(s) | Main effect |
|---|---|---|
| Hypothalamus | Releasing hormones | Links nervous & endocrine systems; controls pituitary |
| Pituitary (anterior) | GH, TSH, ACTH, FSH/LH | Signals other glands |
| Pituitary (posterior) | ADH, oxytocin | Water reabsorption; labor/let-down |
| Thyroid | Thyroxine / calcitonin | Raises metabolism / lowers blood calcium |
| Parathyroid | PTH | Raises blood calcium |
| Pancreas | Insulin / glucagon | Lowers / raises blood glucose |
| Adrenal | Cortisol, epinephrine | Stress response |
Other body systems
Cover the rest broadly. The respiratory path ends at the alveoli (gas exchange), driven by the diaphragm. Digestion runs mouth → esophagus → stomach → small intestine (most absorption) → large intestine (water).
The urinary path is kidney → ureter → bladder → urethra, with the as the filtering unit. In the nervous system, neurons are sensory (toward the CNS) and are motor (away) — mnemonic SAME.[7]
| System | Must-know fact |
|---|---|
| Skeletal | 206 bones; femur is longest/strongest; bones store calcium |
| Muscular | Skeletal (voluntary), cardiac (heart), smooth (organs) |
| Nervous | CNS = brain + spinal cord; SAME = Sensory-Afferent, Motor-Efferent |
| Respiratory | Gas exchange at the alveoli; diaphragm drives breathing |
| Urinary | Nephron filters; path kidney → ureter → bladder → urethra |
| Integumentary | Epidermis (outer) → dermis → hypodermis (fat) |
Checkpoint · Anatomy & Physiology
Question 1 of 10
Which plane divides the body into left and right sides?
Biology
Biology is a school-dependent science section (about 25–30 questions, ~25 minutes) at intro-college level. The highest-confidence “this was on my exam” cluster is cellular respiration and photosynthesis (reactants, products, and ATP yields), mitosis vs. meiosis, transcription/translation, and Punnett squares.[10]
Cells, organelles, and transport
Separate prokaryotes (bacteria — no nucleus) from eukaryotes (nucleus + organelles). Match each to its job: the make ATP, build proteins, the nucleus holds DNA, and the packages and ships proteins. Transport: and are passive, while needs ATP.[9]
Eukaryotic (animal) cell — organelle → function
Cellular respiration vs. photosynthesis
Memorize the two energy equations cold — telling them apart is the most-asked Biology item. burns glucose to make ATP: , running glycolysis (cytoplasm) → Krebs cycle → electron transport chain, for ~36–38 ATP per glucose. is the reverse, building glucose with light: .[10]
Cellular respiration · in mitochondria
C₆H₁₂O₆ + 6 O₂
↓ (releases energy)
6 CO₂ + 6 H₂O + ATP
- Burns glucose to make ATP (~36–38 per glucose)
- Glycolysis (cytoplasm) → Krebs (matrix) → ETC (inner membrane)
- Done by all cells
Photosynthesis · in chloroplasts
6 CO₂ + 6 H₂O + light
↓ (stores energy)
C₆H₁₂O₆ + 6 O₂
- Builds glucose using light energy
- Light reactions (thylakoid) → Calvin cycle (stroma)
- Done by plants (and algae)
They are mirror images: the products of one are the reactants of the other. Memorize both equations cold — telling them apart is the most-asked HESI A2 Biology item.
Cell division, DNA, and genetics
Distinguish (one division → two identical cells, 2n = 46 in humans) from (two divisions → four unique gametes, n = 23). The flows DNA → RNA → protein; DNA pairs A-T and G-C, while RNA uses uracil (U) instead of thymine. A is three mRNA bases for one amino acid (AUG = start).[9]
For Mendelian genetics, a is the genetic makeup (Bb) and a is the observed trait. A monohybrid cross gives a genotype ratio of 1:2:1 and a phenotype ratio of 3:1 (dominant:recessive) on a 2×2 .[9]
Checkpoint · Biology
Question 1 of 10
The concept of gravity put forth by Sir Isaac Newton is an example of:
Chemistry
Chemistry is an uncommon section (about 25–30 questions, ~25 minutes), required by programs with a chemistry prerequisite. It is more conceptual than calculation— atomic structure, the periodic table, bonding, reaction types, and pH — and light on multi-step stoichiometry, so don’t over-drill hard math.[11]
Atomic structure and the periodic table
An atom has protons (+) and neutrons (0) in the nucleus and electrons (−) in shells. The (number of protons) defines the element, and mass number A = protons + neutrons. share an element but differ in neutrons. (outer shell) drive bonding.[11]
The atom — three particles
Mass number A = protons + neutrons (A = Z + N). A neutral atom has equal protons and electrons; gaining/losing electrons makes an ion (anion −, cation +).
On the periodic table, atomic radius decreases left→right and increases down; electronegativity and ionization energy increase toward the top-right (fluorine is most electronegative). Group 18 noble gases are inert (full shell); group 17 halogens are very reactive.[11]
Bonding and reaction types
An transfers electrons (metal + nonmetal, e.g., ); a shares electrons (nonmetals, e.g., ). Balance equations by changing coefficients only, never subscripts — required by .[11]
| Type | General form |
|---|---|
| Synthesis | |
| Decomposition | |
| Single replacement | |
| Double replacement | |
| Combustion | |
| Neutralization |
Acids, bases, the mole, and pH
The runs 0–14: below 7 acidic, 7 neutral, above 7 basic, and pH + pOH = 14. Strong acids (, , ) fully dissociate; strong bases include and .
A is particles (Avogadro’s number), and is moles of solute per liter. Remember for redox.[11]
Strong acid
Stomach acid, lemon
Acidic
Vinegar, soda
Weak acid
Coffee, rain
Neutral
Pure water, blood ≈7.4
Weak base
Baking soda, sea water
Basic
Ammonia
Strong base
Bleach, lye (NaOH)
Checkpoint · Chemistry
Question 1 of 10
Which of the following numbers does the prefix “deka” represent?
Physics
Physics is rare — required only by programs with a physics prerequisite, and it is not in the official Elsevier review book. Confirm your program even requires it before studying. It tests conceptual + light-calculation intro physics: motion, forces, energy, and basic waves and electricity.[18]
Motion, forces, and energy
Distinguish speed (a scalar, distance ÷ time) from (a vector with direction), and distance (total path) from displacement (straight-line). is the change in velocity over time. is , weight is with , and work is .[18]
Energy is conserved (it transforms, never disappears). is , gravitational potential energy is , and power is . Momentum is and is conserved in collisions.[18]
Waves and electricity
A wave transfers energy; wave speed is . Transverse waves (light) vibrate perpendicular to travel; longitudinal waves (sound) vibrate parallel, and sound needs a medium while light travels through a vacuum. is ; in a series circuit current is the same throughout, while in a parallel circuit voltage is the same across branches.[18]
| Quantity | Formula | Unit |
|---|---|---|
| Velocity | m/s | |
| Acceleration | m/s² | |
| Force | newton (N) | |
| Work | joule (J) | |
| Kinetic energy | joule (J) | |
| Wave speed | m/s | |
| Ohm's law | volt (V) |
Checkpoint · Physics
Question 1 of 10
What is the distance a car travels in 6 seconds if it travels at an average speed of 42 m/s?
How to Use This Study Guide
Because the HESI A2 is modular, your first move is to confirm which sections your program requires and what cutoff it sets — then study only those, one at a time. Use this guide alongside our free practice tools, not on its own:
- 1
Confirm your sections
Check your program's required HESI A2 sections and passing score first — don't study Chemistry or Physics if your program doesn't use them.
- 2
Pick one section
Focus on a single required section at a time — start with Math and A&P, where most points are won or lost.
- 3
Read, then test yourself
Read a section here, then take that section's drill on the practice test to expose what didn't stick.
- 4
Drill the gaps
Send your weak topics straight into the free practice test and flashcards.
- 5
Bookmark & space it out
Come back over several days. Short, spaced sessions beat one long cram.
HESI A2 Concept Questions
Common HESI A2 concepts tested across its sections. Tap any card for a short, exam-ready answer backed by an authoritative source — then test yourself on them as flashcards.
HESI A2 Glossary
Quick definitions for the terms you’ll see most across the HESI A2 sections:
- acceleration
- The change in velocity over time, in m/s².
- active transport
- Movement of substances from low to high concentration, requiring ATP.
- acute
- Sudden in onset and short but often severe in course; opposite of chronic.
- affect
- Usually a verb meaning to influence (an Action).
- afferent
- Sensory neurons carrying signals toward the CNS (mnemonic SAME: Sensory-Afferent).
- allele
- A version of a gene; dominant (uppercase) masks recessive (lowercase).
- anterior
- Toward the front of the body (ventral).
- aorta
- The largest artery; carries oxygenated blood from the left ventricle to the body.
- atomic number
- The number of protons in an atom's nucleus; it defines the element.
- author's purpose
- Why a text was written: to inform, persuade, entertain, describe, or instruct.
- benign
- Not harmful; not cancerous.
- cellular respiration
- Converting glucose and oxygen into ATP, CO₂, and water; glycolysis in the cytoplasm, Krebs and the ETC in the mitochondria.
- central dogma
- The flow of genetic information: DNA → RNA → protein.
- chronic
- Long-lasting and persistent.
- codon
- Three mRNA bases that code for one amino acid; AUG is the start codon.
- comma splice
- Two independent clauses joined by only a comma; fix with a period, semicolon, or a conjunction.
- conservation of mass
- Principle that matter is neither created nor destroyed, so atoms must balance in a chemical equation.
- context clue
- A hint in the surrounding sentence — definition, contrast, example, or restatement — that reveals a word's meaning.
- contraindication
- A reason NOT to use a particular treatment.
- covalent bond
- A bond formed by sharing electrons, typically between nonmetals.
- cross-multiplication
- Solving a proportion by setting equal to , then solving for the unknown.
- diffusion
- Movement of particles from high to low concentration (passive, no ATP).
- diploid
- Having the full chromosome number (2n = 46 in humans).
- distal
- Farther from the point of attachment or origin.
- dosage formula
- Amount to give = (Dose Ordered Dose on Hand) Quantity; convert to the same unit first.
- effect
- Usually a noun meaning a result (the rEsult).
- efferent
- Motor neurons carrying signals away from the CNS to muscles (Motor-Efferent).
- Elsevier
- The education company that owns and publishes the HESI (Health Education Systems, Inc.) exams, including the A2; the official content guide is the Admission Assessment Exam Review, 6th edition (2024).
- endocrine gland
- A ductless gland that secretes hormones directly into the blood.
- fact
- A statement that can be verified as true or false.
- fragment
- An incomplete sentence missing a subject, a verb, or a complete thought.
- frontal plane
- The coronal plane; divides the body into front and back.
- genotype
- An organism's genetic makeup (e.g., Bb).
- glucagon
- A pancreatic hormone that raises blood glucose.
- Golgi apparatus
- The organelle that packages, modifies, and ships proteins.
- grain
- An apothecary mass unit; on the HESI A2 use 1 grain = 60 mg (the pure value is ~64.8 mg, but HESI rounds to 60).
- haploid
- Having half the chromosome number (n = 23 in humans), as in gametes.
- HESI A2
- The Health Education Systems, Inc. Admission Assessment (A2), Elsevier's modular nursing- and allied-health-program admission exam. Schools choose which sections applicants take and set their own passing score.
- homophone
- A word that sounds like another but differs in spelling and meaning, such as their, there, and they're.
- inference
- A conclusion a passage logically supports but does not state outright; on HESI A2 it must stay close to the text.
- insulin
- A pancreatic hormone that lowers blood glucose.
- ionic bond
- A bond formed by transferring electrons, typically between a metal and a nonmetal.
- isotope
- Atoms of the same element with different numbers of neutrons.
- kinetic energy
- The energy of motion, .
- lateral
- Away from the midline of the body.
- left ventricle
- The largest, strongest heart chamber; pumps oxygenated blood to the whole body through the aorta.
- main idea
- The single most important point a passage makes; it covers the whole passage, broader than any one detail.
- malignant
- Cancerous; tending to worsen or spread.
- medial
- Toward the midline of the body.
- meiosis
- Cell division producing four genetically unique haploid gametes for reproduction.
- metric ladder
- Kilo-Hecto-Deca-base-Deci-Centi-Milli, each step a factor of 10 (mnemonic: King Henry Died By Drinking Chocolate Milk).
- mitochondria
- The 'powerhouse' organelle; site of cellular respiration and ATP production.
- mitosis
- Cell division producing two genetically identical diploid cells for growth and repair.
- mitral valve
- The bicuspid (two-cusp) left atrioventricular valve (the L in LAB RAT).
- modular exam
- An exam built from selectable sections; each nursing program picks which HESI A2 sections (typically 4–6) its applicants must take, so there is no single fixed length.
- molarity
- Concentration in moles of solute per liter of solution, .
- mole
- An amount equal to Avogadro's number, particles.
- nephron
- The functional filtering unit of the kidney.
- Newton's second law
- Force equals mass times acceleration, .
- occluded
- Blocked or closed off.
- Ohm's law
- Voltage equals current times resistance, .
- OIL RIG
- Oxidation Is Loss, Reduction Is Gain — of electrons.
- opinion
- A belief or judgment that cannot be verified; often signaled by best, should, or unfortunately.
- organelle
- A specialized structure within a cell, such as the mitochondria or nucleus.
- osmosis
- The diffusion of water across a selectively permeable membrane.
- parathyroid
- The gland whose hormone (PTH) raises blood calcium when it drops.
- patent
- Open and unobstructed (a patent airway).
- PEMDAS
- Order of operations: Parentheses, Exponents, Multiplication/Division (left to right), Addition/Subtraction (left to right).
- percent change
- (new value old value) old value ; positive is an increase, negative a decrease.
- pH scale
- A 0–14 logarithmic scale of acidity; below 7 acidic, 7 neutral, above 7 basic.
- phenotype
- An organism's observed physical trait.
- photosynthesis
- Using light to build glucose from CO₂ and water in chloroplasts; the reverse of respiration.
- pilot question
- An unscored trial question (about 5 per section) that does not count toward your score but is mixed in so the administered count exceeds the scored count.
- pituitary
- The 'master gland' that controls other endocrine glands; anterior secretes GH/TSH/ACTH/FSH/LH/prolactin, posterior releases ADH and oxytocin.
- posterior
- Toward the back of the body (dorsal).
- prefix
- A word part added to the front of a root that changes meaning, such as hyper- (over) or hypo- (under).
- proportion
- An equation stating that two ratios are equal, such as ; solved by cross-multiplication.
- proximal
- Closer to the point of attachment or origin.
- pulmonary artery
- The one artery carrying deoxygenated blood, from the right ventricle to the lungs.
- pulmonary vein
- The veins carrying oxygenated blood from the lungs to the left atrium.
- Punnett square
- A grid used to predict offspring genotype and phenotype ratios from a genetic cross.
- ratio
- A comparison of two quantities, written or ; ratios and proportions are the heaviest-weighted HESI A2 math topic.
- ribosome
- The site of protein synthesis.
- root
- The core part of a word carrying its base meaning, such as cardi (heart).
- run-on
- Two independent clauses joined without proper punctuation or a conjunction.
- sagittal plane
- Divides the body into left and right.
- subject-verb agreement
- The rule that a verb must match its subject in number — a singular subject takes a singular verb.
- suffix
- A word part added to the end of a root, often marking a condition or part of speech, such as -itis (inflammation).
- supporting detail
- A specific fact or example that backs up the main idea; never the main idea itself.
- tone
- The author's attitude toward the subject, conveyed through word choice (neutral, critical, enthusiastic, cautionary).
- transverse plane
- Divides the body into top (superior) and bottom (inferior).
- tricuspid valve
- The right atrioventricular valve with three cusps (the R in LAB RAT).
- valence electron
- An outer-shell electron that drives chemical bonding.
- velocity
- Displacement divided by time; a vector with both size and direction (speed is the scalar version).
Free HESI A2 Study Materials & Resources
Everything you need to prepare for the HESI A2 is free here — no paywall, no sign-up. This guide is the foundation; pair it with the rest of our free HESI A2 study materials:
- HESI A2 Practice Test — realistic, timed questions with explanations, by section.
- HESI A2 Flashcards — active-recall decks for the high-yield facts.
HESI A2 Study Guide FAQ
There is no single fixed length — the HESI A2 is modular. Each program picks which sections you take (commonly 4–6). The four core English/Math sections run about 50 scored questions each, so a common 4-section exam is roughly 200 scored questions; science sections add about 25–30 each.
There is no universal passing score. Each nursing or allied-health program sets its own cutoff, commonly around 75–80%, with 85%+ competitive at selective programs. Many programs also require a minimum on each section, so confirm your target program's exact rules.
Up to eight academic sections exist: Mathematics, Reading Comprehension, Vocabulary & General Knowledge, Grammar, Anatomy & Physiology, Biology, Chemistry, and Physics. The four English/Math sections plus A&P are most common; Chemistry and Physics are required only by some programs.
Most administrations provide an on-screen drop-down calculator, but many testing centers do not — and there is no formula or conversion sheet. Because conversions and proportions dominate, memorize equivalents (such as 1 kg = 2.2 lb and 1 grain = 60 mg) so you can work without leaning on a calculator.
Anatomy & Physiology is the most-feared science section because of its breadth and applied physiology, and Math is high-stakes because conversions and proportions make up most of it. Vocabulary is a 'sleeper' — easy to study but tested with everyday words the official book omits.
Both are nursing-admission exams, but the HESI A2 is owned by Elsevier and is modular (schools pick the sections and cut score), while the TEAS is owned by ATI with four fixed sections. Use only HESI A2 materials if your program requires the HESI.
First confirm which sections your program requires, then study those one at a time. Read a section here, test yourself with our free practice test, and drill the questions you miss with the flashcards. This guide is a high-yield overview, not a full textbook.
Yes — the full guide, the glossary, the practice test, and the flashcards are 100% free with no account required.
References
- 1.Elsevier / HESI. “Admission Assessment Exam Review, 6th Edition (HESI).” Elsevier. ↑
- 2.Elsevier. “HESI Exam Solutions for Nursing (Admission Assessment Overview).” Elsevier. ↑
- 3.Elsevier Evolve. “HESI A2 and à la carte Exams (Modular Section Selection).” Elsevier Evolve. ↑
- 4.Elsevier Evolve. “Official HESI A2 Student Guide (Own Device).” Elsevier Evolve. ↑
- 5.Elsevier Evolve. “How to Study for Entrance Exams (Student Life Blog).” Elsevier Evolve. ↑
- 6.National Heart, Lung, and Blood Institute (NIH). “How the Heart Works: Blood Flow.” nhlbi.nih.gov. ↑
- 7.National Cancer Institute SEER Training (NIH). “Cardiovascular System and Anatomical Terminology.” training.seer.cancer.gov. ↑
- 8.MedlinePlus, U.S. National Library of Medicine (NIH). “Endocrine Glands, Hormones, and Medical Word Parts.” medlineplus.gov. ↑
- 9.National Human Genome Research Institute (NIH). “Cell Biology, Organelles, DNA, and Cell Division (Genetics Glossary).” genome.gov. ↑
- 10.National Center for Biotechnology Information (NIH). “Cellular Respiration and Photosynthesis (Biochemistry).” ncbi.nlm.nih.gov. ↑
- 11.National Institute of Standards and Technology (NIST). “Atomic Structure, Bonding, and the pH Scale (Periodic Table).” nist.gov. ↑
- 12.National Institute of Standards and Technology (NIST). “The Metric System, Ratios, and Unit Conversion.” nist.gov. ↑
- 13.National Library of Medicine (NIH), Bookshelf. “Dosage Calculation and Safe Medication Administration.” ncbi.nlm.nih.gov. ↑
- 14.Purdue Online Writing Lab (Purdue University). “Reading Comprehension: Main Idea, Inference, and Author's Purpose.” owl.purdue.edu. ↑
- 15.Purdue Online Writing Lab (Purdue University). “Grammar, Sentence Structure, Agreement, and Punctuation.” owl.purdue.edu. ↑
- 16.Purdue Online Writing Lab (Purdue University). “Commonly Confused Words and Spelling Conventions.” owl.purdue.edu. ↑
- 17.MedlinePlus, U.S. National Library of Medicine (NIH). “Understanding Medical Words: Prefixes, Roots, and Suffixes.” medlineplus.gov. ↑
- 18.NASA Glenn Research Center. “Motion, Forces, Energy, and Waves (Physics Basics).” nasa.gov. ↑
Sources for the concept answers
Every answer in the HESI A2 concept questions above is drawn from an official or authoritative primary source:
- National Cancer Institute SEER Training (NIH). “Anatomical Terminology, Planes, and Directions.” training.seer.cancer.gov, accessed 18 June 2026.

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