This free Praxis General Science (5435) study guide teaches to the ETS Praxis General Science: Content Knowledge test — every content category the exam measures, organized the way ETS builds the test.[1] The 5435 is the licensure exam for prospective secondary general-science teachers, and it is broad rather than deep: it samples introductory physics, chemistry, biology, and earth and space science.
Because the test spans four categories, this guide covers all of them — the and of Physical Science, the cells, of Life Science, and the geology and of Earth and Space Science — plus the nature-of-science skills that thread through all of them. It’s interactive, not a wall of text: every category has a built-in checkpoint quiz, hover-able glossary terms, worked examples, and concept questions.
Read this guide category by category, test yourself at each checkpoint, then round out your free Praxis 5435 prep with our practice questions and flashcards.
Praxis 5435 is one of the 7 Praxis exams — explore our Praxis study guides to compare and prep across the whole family.
Praxis 5435 Exam Snapshot
| Detail | Praxis General Science (5435) |
|---|---|
| Questions | About 135 selected-response questions |
| Format | Computer-delivered; single-answer and multiple-answer questions |
| Total time | 2 hours 30 minutes (150 minutes) |
| Score scale | 100–200 scaled score |
| Passing score | Set by each state/agency (commonly ~141; varies — confirm yours) |
| Content categories | Nature & Impact of Science (~15%), Physical Science (~37%), Life Science (~26%), Earth & Space Science (~22%) |
| Tools provided | On-screen calculator and a list of constants/conversions |
| Who takes it | Prospective secondary general-science teachers |
| Publisher | ETS (Educational Testing Service) |
About 135 selected-response questions in 2.5 hours. Physical Science is the single biggest category — roughly a third of the test.
The four content categories are not weighted equally. Physical Scienceis the single biggest category — roughly a third of the test — so it deserves the most study time, followed by Life Science and Earth & Space Science.[1] Spread your work across all four, but lead with the categories that carry the most questions:
ETS reports the number of questions in each category, which we have expressed as approximate percentages of the roughly 135 total.[1]This guide teaches all four categories as four study modules, starting with the broad nature-of-science skills and then moving through Physical, Life, and Earth & Space Science.
1 · Nature & Impact of Science & Engineering
About 15% of the test (~20 questions). This category is about how science works — designing experiments, measuring and interpreting data, and the relationship among science, engineering, technology, and society.[1]
Scientific Method & Experiments
A controlled experiment changes one and measures its effect on a , while holding every other factor constant and including a for comparison. A good is testable and falsifiable — there must be a way to prove it wrong.
Conclusions feed new questions, so the process cycles rather than ending — that is what makes science self-correcting.
- 1. Ask a questionObserve something and pose a testable question about it.
- 2. Form a hypothesisPropose a falsifiable explanation, often an 'if/then' prediction.
- 3. Design an experimentChange one independent variable; hold all others constant; include a control group.
- 4. Collect & analyze dataMeasure the dependent variable; look for patterns, accounting for error.
- 5. Draw a conclusionDecide whether the data support or refute the hypothesis.
New questions ↺ — a conclusion usually leads back to step 1 with a refined question.
Measurement, Accuracy & Error
is closeness to the true value; is closeness of repeated readings to each other. A miscalibrated balance that always reads high is precise but inaccurate — that is a systematic error. Random error scatters readings and is reduced by averaging trials.
| Term | What it means |
|---|---|
| Accurate | Close to the true value |
| Precise | Repeated measurements close to each other (but maybe not to the truth) |
| Systematic error | A consistent shift in one direction — hurts accuracy; fix at the source |
| Random error | Unpredictable scatter — reduced by averaging many trials |
| SI base units | Meter, kilogram, second, kelvin, ampere, mole, candela |
Engineering, Technology & Society
Science seeks to understand the natural world; engineering applies that understanding to design solutions within real-world constraints such as cost, time, and safety. The engineering design process is iterative: define the problem, brainstorm, prototype, test, and redesign. Scientific and technological advances reshape society and raise ethical and environmental questions.
Checkpoint · Category 1 · Nature & Impact of Science
Question 1 of 10
In a well-designed experiment, what is the role of the independent variable?
2 · Physical Science
About 37% of the test (~50 questions) — the single biggest category. Physical Science is chemistry and physics: atoms and the periodic table, bonding and reactions, and forces, energy, waves, electricity, and magnetism.[1]
Atoms & the Periodic Table
An atom has protons and neutrons in its nucleus and electrons around it. The (protons) defines the element; the mass number is protons plus neutrons. differ in neutrons, and an has gained or lost electrons. Elements in the same group share properties because they have the same number of valence electrons.
| Trend | Right → Left across a period | Top → Bottom down a group |
|---|---|---|
| Atomic radius | increases | increases |
| Ionization energy | decreases | decreases |
| Electronegativity | decreases | decreases |
| Metallic character | increases | increases |
Read across a period (a row) and down a group (a column). Atomic radius is the master trend — the others largely follow how tightly the nucleus holds the outer electrons.
Bonding, Reactions & Matter
An transfers electrons from a metal to a nonmetal; a shares electrons between nonmetals. Every reaction obeys , which is why chemical equations must be balanced. Acids donate H⁺ ions (pH below 7); bases accept them (pH above 7).
Forces, Motion & Energy
says net force equals mass times acceleration, . is and gravitational potential energy is . By the , energy only changes form — it is never lost.
Waves, Electricity & Magnetism
Wave speed is (frequency times wavelength). The runs from radio (low energy) to gamma rays (high energy).[4] In circuits, Ohm’s law is ; in a series circuit current is the same everywhere, while in a parallel circuit voltage is the same across branches.
| Quantity | Relationship |
|---|---|
| Newton's second law | |
| Density | |
| Kinetic energy | |
| Wave speed | |
| Ohm's law |
Checkpoint · Category 2 · Physical Science
Question 1 of 10
What three subatomic particles make up a neutral atom, and where is most of its mass located?
3 · Life Science
About 26% of the test (~35 questions). Life Science covers cells and their energy processes, genetics and heredity, evolution and classification, and ecology.[1]
Cells & Energy (Photosynthesis & Respiration)
says all living things are made of cells that come from pre-existing cells. in the chloroplast stores light energy in glucose, and in the mitochondria releases it as — the two are nearly reverse processes.
The products of one are the reactants of the other — oxygen and glucose cycle between plants and all respiring cells, balancing carbon and energy in living systems.
Genetics & Heredity
DNA stores genetic information in base pairs (A-T, G-C). A is expressed when present; a recessive allele only shows with two copies. A Punnett square predicts offspring ratios. makes two identical cells for growth; makes four varied gametes for reproduction.
Evolution & Classification
drives evolution: individuals with traits better suited to their environment survive and reproduce more, shifting a population over generations.[6] Mutation supplies the variation selection acts on. Organisms are classified in the order Domain, Kingdom, Phylum, Class, Order, Family, Genus, Species.
Ecology & Ecosystems
Energy flows one way through a food web: producers capture sunlight, consumers eat them, and decomposers recycle nutrients — with only about 10% of energy passing to each higher level. Matter, by contrast, cycles (the carbon, nitrogen, and water cycles).
Checkpoint · Category 3 · Life Science
Question 1 of 10
What is the overall purpose of photosynthesis in green plants?
4 · Earth & Space Science
About 22% of the test (~30 questions).Earth and Space Science covers Earth’s structure and plate tectonics, rocks and geologic time, the atmosphere and weather, and basic astronomy.[1]
Earth’s Structure & Plate Tectonics
Earth’s layers, from outside in, are crust, mantle, liquid outer core, and solid inner core. explains how mantle convection moves the plates, producing earthquakes, volcanoes, and mountains along their boundaries.[5]
Mantle convection drives all three. Most earthquakes and volcanoes cluster along these boundaries.
Rocks, Minerals & Geologic Time
The three rock types — , , and — continuously transform through the rock cycle. Fossils form mostly in sedimentary rock, and the says deeper layers are older.
- Igneous rockCooling & solidifying of magma or lava
- Sedimentary rockWeathering, then compaction & cementation of sediments
- Metamorphic rockHeat & pressure transform existing rock
Any rock can become any other: melting forms igneous, weathering and burial form sedimentary, and heat and pressure form metamorphic — continuously, over geologic time.
Atmosphere, Weather & Water
The atmosphere layers (troposphere, stratosphere with its ozone, mesosphere, thermosphere) surround Earth. The water cycle moves water through evaporation, condensation, and precipitation, and the traps heat that keeps Earth warm — with excess gas intensifying it. Weather is short-term; climate is the long-term average.
Astronomy & the Solar System
The eight planets orbit the Sun, a star powered by nuclear fusion. Earth’s daily rotation causes day and night, while its yearly revolution and the 23.5° axial tilt cause the seasons — not its distance from the Sun.[7] Moon phases and eclipses come from the Sun-Earth-Moon geometry.
Checkpoint · Category 4 · Earth & Space Science
Question 1 of 10
Which layer of Earth lies directly beneath the crust and behaves as a slowly flowing solid that drives the movement of tectonic plates?
How to Use This Study Guide
A study guide is a map, not the whole territory — use it alongside the official ETS materials and our free tools. Because the 5435 is broad, the goal is even coverage across all four categories, so spaced, mixed practice beats one long cram. Lead with Physical Science (the biggest category), and give extra time to whichever science you studied least in school.
- 1
Read a category here
Work through one content category at a time — start with Physical Science, the heaviest.
- 2
Take the checkpoint
The quick check at the end of each category exposes what didn't stick.
- 3
Drill the gaps
Send your weak category straight into the free practice questions and flashcards.
- 4
Take full, timed practice
Sit a full practice test to build stamina across all four categories, then review every miss.
Praxis 5435 Concept Questions
Common science concepts the Praxis 5435 actually measures — at least one per content category. Tap any card for a short, exam-ready answer backed by an authoritative source (ETS, NASA, USGS, and the NIH), then test yourself on them as flashcards.
Praxis 5435 Glossary
Quick definitions for the terms you’ll see most across the Praxis General Science (5435):
- Accuracy
- How close a measurement is to the true value. Distinct from precision, which is how close repeated measurements are to each other.
- Atomic number
- The number of protons in an atom, which defines the element's identity.
- ATP
- Adenosine triphosphate — the cell's main energy-carrying molecule, produced by cellular respiration.
- Cell theory
- The principle that all living things are made of cells, the cell is the basic unit of life, and all cells come from pre-existing cells.
- Cellular respiration
- The process by which cells break down glucose with oxygen to release energy as ATP, mainly in the mitochondria.
- Conservation of energy
- Energy cannot be created or destroyed, only transformed; the total energy of a closed system stays constant.
- Conservation of mass
- The principle that mass is neither created nor destroyed in a chemical reaction, so reactant mass equals product mass.
- Control group
- The group in an experiment that does not receive the treatment, providing a baseline for comparison.
- Covalent bond
- A chemical bond formed when two nonmetal atoms share electrons.
- Dependent variable
- The outcome measured in an experiment; it responds to (depends on) the independent variable and is plotted on the y-axis.
- Dominant allele
- A version of a gene that is expressed whenever it is present, masking a recessive allele.
- Electromagnetic spectrum
- The full range of electromagnetic waves — radio, microwave, infrared, visible, ultraviolet, X-ray, gamma — ordered by frequency and energy.
- Electronegativity
- A measure of an atom's tendency to attract bonding electrons; it increases up and to the right on the periodic table, peaking at fluorine.
- Greenhouse effect
- The warming of Earth's surface when atmospheric gases such as carbon dioxide and water vapor trap heat radiating from the surface.
- Hypothesis
- A testable, falsifiable proposed explanation, often stated as an 'if/then' prediction about how variables relate.
- Igneous rock
- Rock formed from the cooling and solidifying of molten magma or lava.
- Independent variable
- The factor a researcher deliberately changes in an experiment to test its effect; it is plotted on the x-axis.
- Ion
- An atom that has gained or lost electrons, giving it a net negative or positive charge.
- Ionic bond
- A bond formed by the transfer of electrons from a metal to a nonmetal, creating oppositely charged ions that attract.
- Isotope
- An atom of an element with the same number of protons but a different number of neutrons, giving it a different mass number.
- Kinetic energy
- The energy of motion, equal to one-half mass times velocity squared (KE = ½mv²); it grows with the square of speed.
- Law of superposition
- In undisturbed rock layers, the oldest layers lie at the bottom and the youngest at the top.
- Meiosis
- Cell division producing four genetically varied haploid gametes with half the chromosome number.
- Metamorphic rock
- Rock formed when existing rock is transformed by heat and pressure, such as marble from limestone.
- Mitosis
- Cell division producing two genetically identical diploid cells, used for growth and repair.
- Natural selection
- The process by which individuals with traits better suited to their environment survive and reproduce more, shifting a population's traits over generations.
- Newton's second law
- The net force on an object equals its mass times its acceleration, written F = ma.
- Photosynthesis
- The process by which plants use light energy to convert carbon dioxide and water into glucose and oxygen, in the chloroplast.
- Plate tectonics
- The theory that Earth's rigid outer shell is broken into plates that slowly move over the softer mantle, driven by convection.
- Precision
- How close repeated measurements are to one another. Measurements can be precise but inaccurate if a systematic error shifts them all.
- Scientific theory
- A broad, well-substantiated explanation supported by a large body of evidence, such as evolution or plate tectonics — far stronger than a guess.
- Sedimentary rock
- Rock formed when sediments are compacted and cemented over time; it often contains fossils.
Free Praxis 5435 Study Materials & Resources
Everything you need to prepare for the Praxis General Science (5435) is free here — no paywall, no sign-up. This guide is the foundation; pair it with the rest of our free Praxis 5435 study materials for active recall, timed practice, and last-minute review:
- Praxis 5435 Practice Test — exam-style questions across all four content categories, with explanations.
- Praxis 5435 Flashcards — active-recall decks for the high-yield science facts, formulas, and vocabulary.
Praxis 5435 Study Guide FAQ
The Praxis General Science: Content Knowledge (5435) test has about 135 selected-response questions and a total testing time of 2.5 hours. The questions are drawn from four content categories: Nature and Impact of Science and Engineering, Physical Science, Life Science, and Earth and Space Science.
Total testing time is 2 hours and 30 minutes (150 minutes) for the roughly 135 selected-response questions. It is delivered on computer at Praxis test centers and through at-home testing where available.
Praxis 5435 is reported on a 100–200 scaled-score range, and the passing score is set by each state or licensing agency, not by ETS. Many states require around 141, but cutoffs vary — for example, some jurisdictions set it higher. Always confirm the exact passing score required where you plan to teach.
Four content categories: Nature and Impact of Science and Engineering (scientific method, measurement, engineering design), Physical Science (chemistry and physics), Life Science (cells, genetics, evolution, ecology), and Earth and Space Science (geology, the atmosphere, and astronomy). Physical Science is the largest category.
The 5435 is broad rather than deep — it samples introductory physics, chemistry, biology, and earth and space science, so the challenge is range, not advanced difficulty. Candidates who studied one science area but not the others should focus their review on the unfamiliar categories, especially Physical Science.
Work through all four content categories module by module, starting with Physical Science since it carries the most weight. After each module, take the checkpoint quiz to find gaps, then drill that category with our free practice questions and flashcards before sitting a full, timed practice test.
An on-screen calculator and a list of physical constants and conversions are provided for the relevant questions, so you do not need to memorize numeric constants. You should still know the core relationships — such as F = ma, density = mass ÷ volume, and the photosynthesis and respiration equations — well enough to apply them quickly.
Yes — the full guide, the checkpoints, the glossary, the practice questions, and the flashcards are 100% free, with no account required.
References
- 1.ETS. “Praxis General Science: Content Knowledge (5435) — Test Overview.” ETS. ↑
- 2.ETS. “About The Praxis Tests.” ETS. ↑
- 3.ETS. “Praxis Tests — Understanding Your Praxis Scores.” ETS. ↑
- 4.NASA Science. “Introduction to the Electromagnetic Spectrum.” NASA. ↑
- 5.U.S. Geological Survey. “Understanding Plate Motions.” USGS. ↑
- 6.National Human Genome Research Institute. “Evolution — Genetics Glossary.” NHGRI. ↑
- 7.NASA Space Place. “What Causes the Seasons?.” NASA. ↑
Sources for the concept answers
Every answer in the Praxis 5435 concept questions above is drawn from an official or authoritative primary source:
- National Institute of General Medical Sciences. “Cells: The Basic Units of Life.” National Institute of General Medical Sciences.
- National Human Genome Research Institute. “Genetics Glossary — Allele.” National Human Genome Research Institute.
- NOAA. “Food Webs and the Ocean.” NOAA.
- U.S. Geological Survey. “Rock Cycle.” U.S. Geological Survey.

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