- Lithium therapeutic range
- 0.8–1.2 mEq/L acute, 0.8–1.0 maintenance (FDA); toxicity ≥1.5 mEq/L; draw a 12-hour trough.
- Mesolimbic dopamine pathway
- VTA → nucleus accumbens; overactivity = positive psychotic symptoms (hallucinations, delusions); target of antipsychotic D2 blockade.
- Mesocortical dopamine pathway
- VTA → prefrontal cortex; underactivity = negative/cognitive symptoms of schizophrenia.
- Nigrostriatal dopamine pathway
- Substantia nigra → striatum; D2 blockade here causes EPS (parkinsonism, dystonia, akathisia, tardive dyskinesia).
- Tuberoinfundibular dopamine pathway
- Hypothalamus → pituitary; dopamine inhibits prolactin; D2 blockade → hyperprolactinemia (galactorrhea, amenorrhea, gynecomastia).
- Amygdala
- Fear processing and threat detection; hyperactive in anxiety and PTSD.
- Hippocampus
- Memory consolidation; atrophies with chronic stress/cortisol and in depression/PTSD.
- Prefrontal cortex
- Executive function and impulse control; matures into the mid-20s (relevant to adolescent risk-taking).
- HPA axis
- Hypothalamus → pituitary → adrenal; chronic activation raises cortisol; dysregulated in depression.
- GABA
- Principal inhibitory neurotransmitter; target of benzodiazepines, barbiturates, alcohol, and Z-drugs.
- Glutamate
- Principal excitatory neurotransmitter; NMDA-receptor target of ketamine/esketamine and memantine.
- Serotonin (5-HT)
- Regulates mood, sleep, appetite, and anxiety; raised by SSRIs, SNRIs, and MAOIs.
- Norepinephrine (NE)
- Arousal, attention, and stress response; raised by SNRIs, TCAs, MAOIs, and atomoxetine.
- Acetylcholine (ACh)
- Memory and cognition; blockade causes anticholinergic effects; deficient in Alzheimer disease (treated with cholinesterase inhibitors).
- ADME
- Absorption, Distribution, Metabolism, Excretion — the four pharmacokinetic processes.
- Half-life (t1/2)
- Time for plasma concentration to fall by 50%; about 5 half-lives to reach steady state or clear a drug.
- CYP2D6 inhibitors (psych)
- Fluoxetine, paroxetine, and bupropion raise levels of 2D6 substrates.
- CYP1A2 induction by smoking
- Tobacco smoke induces 1A2, lowering clozapine/olanzapine levels; quitting raises levels (toxicity risk).
- CYP1A2 inhibitor
- Fluvoxamine raises clozapine, olanzapine, and caffeine levels.
- CYP3A4
- Metabolizes many psychotropics; inhibited by grapefruit and ketoconazole; induced by carbamazepine.
- Carbamazepine autoinduction
- Induces its own metabolism (and 3A4), lowering its own and other drug levels over 2–4 weeks.
- CYP2D6 poor metabolizer
- Higher drug levels and toxicity at standard doses of 2D6 substrates (many antidepressants).
- CYP2D6 ultrarapid metabolizer
- Subtherapeutic levels and treatment failure at standard doses.
- Acute dystonia
- Sustained muscle contraction (torticollis, oculogyric crisis) hours–days after an antipsychotic; treat with IM/IV benztropine or diphenhydramine.
- Akathisia
- Subjective inner restlessness/inability to sit still; treat by lowering dose, propranolol, benztropine, or a benzodiazepine.
- Drug-induced parkinsonism
- Bradykinesia, rigidity, and tremor from D2 blockade; treat with an anticholinergic or dose reduction.
- Tardive dyskinesia (TD)
- Late-onset involuntary choreoathetoid movements (lip-smacking, tongue) from chronic D2 blockade; treat with VMAT2 inhibitors (valbenazine, deutetrabenazine); often irreversible.
- AIMS
- Abnormal Involuntary Movement Scale — screens for tardive dyskinesia.
- Neuroleptic malignant syndrome (NMS)
- Fever, 'lead-pipe' rigidity, autonomic instability, altered mental status, elevated CK from D2 blockade; stop the drug, give dantrolene/bromocriptine, support.
- Serotonin syndrome
- Triad of mental-status change, autonomic instability, and neuromuscular hyperactivity (clonus, hyperreflexia); rapid onset; stop serotonergic agents, give cyproheptadine, support.
- NMS vs serotonin syndrome
- NMS = rigidity + bradyreflexia, slow onset (days); serotonin syndrome = hyperreflexia/clonus, fast onset (hours).
- HLA-B*1502
- Allele (common in some Asian populations) predicting carbamazepine/oxcarbazepine Stevens-Johnson syndrome; screen before starting.
- Heritability of schizophrenia
- About 80%; bipolar disorder about 60–85% — among the most heritable psychiatric disorders.
- Pharmacogenomic testing
- CYP2D6/2C19 genotyping can guide antidepressant selection and dosing (CPIC guidelines).
- Advanced physical assessment (PMHNP)
- Systematic exam to identify medical causes/comorbidities of psychiatric presentations (e.g., thyroid, neurologic).
- PHQ-9
- 9-item depression screen/severity, 0–27; ≥10 = moderate (treatment threshold); item 9 screens suicidality.
- PHQ-9 severity bands
- 5–9 mild, 10–14 moderate, 15–19 moderately severe, 20–27 severe.
- GAD-7
- 7-item generalized-anxiety screen, 0–21; ≥10 = moderate anxiety (clinically significant).
- GAD-7 bands
- 5 mild, 10 moderate, 15 severe.
- Vanderbilt ADHD scale
- Parent/teacher rating used for childhood ADHD diagnosis and monitoring.
- MDQ (Mood Disorder Questionnaire)
- Screens for bipolar-spectrum disorder.
- C-SSRS
- Columbia-Suicide Severity Rating Scale; assesses suicidal-ideation severity and behavior.
- GDS
- Geriatric Depression Scale; depression screen designed for older adults.
- EPDS
- Edinburgh Postnatal Depression Scale; perinatal/postpartum depression screen.
- MoCA vs MMSE
- Cognitive screens; MoCA is more sensitive for mild cognitive impairment; MMSE ≤23–24 suggests impairment.
- PCL-5
- PTSD Checklist for DSM-5; self-report PTSD symptom screen.
- Y-BOCS
- Yale-Brown Obsessive Compulsive Scale; measures OCD severity.
- AUDIT
- 10-item alcohol-use screen (WHO); ≥8 indicates hazardous drinking.
- DAST
- Drug Abuse Screening Test; screens non-alcohol drug use.
- CAGE
- 4-item alcohol screen (Cut down, Annoyed, Guilty, Eye-opener); ≥2 is positive.
- CRAFFT
- Adolescent substance-use screen.
- CIWA-Ar
- Rates alcohol-withdrawal severity; ≥8–10 = medicate (benzodiazepines); ≥15 = high risk of seizures/DTs.
- COWS
- Clinical Opiate Withdrawal Scale; 5–12 mild, 13–24 moderate, 25–36 moderately severe, >36 severe.
- MSE components
- Appearance, Behavior, Speech, Mood, Affect, Thought process, Thought content, Perception, Cognition, Insight, Judgment.
- Mood vs affect
- Mood = the patient's stated, sustained emotion (subjective); affect = the observed emotional expression (objective).
- Thought process
- Form of thinking: linear, tangential, circumstantial, loose associations, flight of ideas, word salad.
- Thought content
- What the patient thinks: delusions, obsessions, suicidal/homicidal ideation, paranoia.
- Motivational interviewing (MI)
- Collaborative, patient-centered method to strengthen change motivation; uses OARS (Open questions, Affirmations, Reflective listening, Summaries); rolls with resistance.
- Open-ended questions
- Encourage elaboration; preferred over yes/no questions in clinical interviewing.
- Strongest predictor of future suicide
- A previous suicide attempt.
- Acute suicide risk factors
- Prior attempt (strongest), a plan with means/access, hopelessness, recent loss, substance use, command hallucinations.
- Means restriction
- Limiting access to lethal means (firearms, medications) is an evidence-based suicide-prevention intervention.
- Safety planning
- Collaborative written plan: warning signs, coping strategies, supports, means restriction, crisis contacts.
- Psychiatric-emergency priorities
- Ensure safety first (patient/staff/others); de-escalate before chemical or physical restraint; use the least restrictive option.
- Levels of prevention
- Primary = prevent onset (education, vaccination); secondary = early detection/screening; tertiary = reduce complications of established disease.
- SAMHSA recovery model
- Recovery is person-driven, holistic, and hope-based; emphasizes resilience and protective factors.
- Psychoeducation
- Teaching patients/families about illness and treatment to improve adherence and outcomes; tailor method and topic to the learner.
- MDD (DSM-5-TR)
- ≥5 symptoms for ≥2 weeks including depressed mood OR anhedonia; mnemonic SIGECAPS.
- SIGECAPS
- MDD symptom mnemonic: Sleep, Interest, Guilt, Energy, Concentration, Appetite, Psychomotor, Suicidality.
- Persistent depressive disorder (dysthymia)
- Depressed mood most days for ≥2 years (1 year in children/adolescents).
- Bipolar I
- At least one manic episode (≥1 week or hospitalization); a depressive episode is not required.
- Bipolar II
- At least one hypomanic episode (≥4 days) plus at least one major depressive episode; no full mania.
- Manic episode (DIGFAST)
- Distractibility, Impulsivity/Indiscretion, Grandiosity, Flight of ideas, Activity increase, Sleep decreased, Talkativeness.
- GAD (DSM-5-TR)
- Excessive worry more days than not for ≥6 months plus ≥3 physical symptoms (restlessness, fatigue, concentration, irritability, muscle tension, sleep).
- Panic disorder
- Recurrent unexpected panic attacks plus ≥1 month of worry about attacks or behavior change.
- Social anxiety disorder
- Marked fear of social/performance situations with scrutiny, lasting ≥6 months.
- OCD
- Obsessions and/or compulsions that are time-consuming (>1 hr/day) or cause distress/impairment.
- PTSD
- Trauma exposure plus intrusion, avoidance, negative cognitions/mood, and arousal/reactivity for >1 month.
- Acute stress disorder
- Trauma-related symptoms lasting 3 days–1 month (vs PTSD >1 month).
- Schizophrenia (DSM-5-TR)
- ≥2 of delusions, hallucinations, disorganized speech, disorganized/catatonic behavior, negative symptoms for ≥1 month, with ≥6 months of disturbance.
- Schizophreniform vs schizophrenia
- Schizophreniform = 1–6 months of symptoms; schizophrenia ≥6 months.
- Schizoaffective disorder
- A mood episode concurrent with schizophrenia symptoms plus ≥2 weeks of psychosis WITHOUT mood symptoms.
- Brief psychotic disorder
- Psychotic symptoms 1 day–1 month with full return to baseline.
- ADHD (DSM-5-TR)
- Inattentive and/or hyperactive-impulsive symptoms, several before age 12, in ≥2 settings.
- Autism spectrum disorder
- Persistent deficits in social communication plus restricted/repetitive behaviors; early developmental onset.
- Anorexia nervosa
- Restriction → low body weight, intense fear of weight gain, body-image disturbance.
- Bulimia nervosa
- Binge eating plus compensatory behaviors ≥1/week for 3 months; usually normal weight.
- Borderline personality disorder
- Instability of relationships, self-image, and affect plus impulsivity; fear of abandonment, splitting, self-harm.
- Antisocial personality disorder
- Disregard for/violation of others' rights since age 15; requires age ≥18 and conduct disorder before 15.
- Delirium
- Acute, fluctuating disturbance of attention/awareness from a medical cause; reversible.
- Delirium vs dementia
- Delirium = acute, fluctuating, altered consciousness, reversible; dementia = gradual, progressive, clear consciousness.
- SSRIs
- First-line for depression/anxiety; block serotonin reuptake (sertraline, escitalopram, fluoxetine).
- SSRI side effects
- GI upset, sexual dysfunction, insomnia/sedation, initial anxiety, hyponatremia (SIADH), serotonin-syndrome risk.
- Antidepressant boxed warning
- Increased suicidal ideation/behavior in patients under 25; monitor closely early in treatment.
- SNRIs
- Venlafaxine, duloxetine, desvenlafaxine; raise serotonin and norepinephrine; can raise blood pressure.
- SNRI vs SSRI
- SNRIs add norepinephrine reuptake inhibition (useful for pain/low energy); more discontinuation symptoms (venlafaxine).
- TCAs
- Amitriptyline, nortriptyline; effective but anticholinergic and cardiotoxic (QRS widening); lethal in overdose.
- MAOIs
- Phenelzine, tranylcypromine, selegiline; require a tyramine-free diet (avoid aged cheese, cured meats, fermented foods) to prevent hypertensive crisis.
- MAOI washout
- ≥2 weeks between an MAOI and other serotonergic agents (5 weeks after fluoxetine) to avoid serotonin syndrome.
- Bupropion
- NDRI; no sexual dysfunction or weight gain; lowers seizure threshold (avoid in eating/seizure disorders); aids smoking cessation.
- Mirtazapine
- Alpha-2 antagonist; sedating and increases appetite (useful for insomnia/low weight in depression).
- Trazodone
- Serotonin modulator; used off-label for insomnia; risk of priapism.
- Vortioxetine
- Multimodal antidepressant with possible pro-cognitive benefit.
- Lithium
- First-line for bipolar mania/maintenance; FDA range 0.8–1.2 acute / 0.8–1.0 maintenance mEq/L, toxicity ≥1.5; monitor renal function and TSH; teratogenic (Ebstein anomaly).
- Lithium toxicity
- Tremor, ataxia, confusion, seizures; worsened by dehydration, NSAIDs, thiazides, and ACE inhibitors (reduce lithium clearance).
- Valproate
- For mania/seizures; monitor LFTs and platelets; boxed warnings for hepatotoxicity, pancreatitis, and teratogenicity (neural-tube defects).
- Carbamazepine
- Mood stabilizer/anticonvulsant; risk of agranulocytosis/aplastic anemia (monitor CBC), HLA-B*1502 SJS, autoinduction, and hyponatremia.
- Lamotrigine
- Bipolar-depression maintenance; titrate slowly to avoid Stevens-Johnson syndrome / TEN (boxed warning for serious rash).
- First-generation (typical) antipsychotics
- Haloperidol, chlorpromazine; high D2 blockade → more EPS.
- Second-generation (atypical) antipsychotics
- Risperidone, olanzapine, quetiapine, aripiprazole; less EPS, more metabolic side effects.
- Metabolic monitoring (atypicals)
- Weight/BMI, fasting glucose, lipids, and blood pressure at baseline and periodically (weight gain, diabetes, dyslipidemia).
- Clozapine
- Most effective for treatment-resistant schizophrenia; boxed warnings: agranulocytosis (ANC monitoring), seizures, myocarditis, orthostatic hypotension, GI hypomotility/ileus.
- Clozapine ANC monitoring
- Weekly ANC initially; hold if ANC <1,000/µL (general population). The FDA REMOVED the Clozapine REMS in 2025, but label-schedule ANC monitoring is still recommended.
- Antipsychotic + dementia boxed warning
- Increased mortality in elderly patients with dementia-related psychosis (not an FDA-approved use).
- QTc prolongation
- Caused by many antipsychotics (e.g., ziprasidone, IV haloperidol); risk of torsades de pointes.
- Aripiprazole
- D2 partial agonist; lower metabolic burden; can cause akathisia.
- Stimulants (ADHD)
- Methylphenidate, amphetamine salts; first-line for ADHD; controlled substances; boxed warning for abuse/dependence; monitor cardiovascular status, growth, BP/HR.
- Atomoxetine
- Nonstimulant (NRI) for ADHD; boxed warning for suicidal ideation in children/adolescents.
- Benzodiazepines
- Enhance GABA; rapid anxiolytic but risk of dependence/tolerance/withdrawal; boxed warning with opioids (respiratory depression/death).
- Benzodiazepine withdrawal
- Anxiety, insomnia, tremor, seizures; potentially life-threatening; taper gradually.
- Buspirone
- 5-HT1A partial agonist; non-sedating, non-dependence anxiolytic; takes 2–4 weeks (not PRN).
- Naltrexone
- Opioid antagonist for alcohol and opioid use disorder; must be opioid-free ~7–10 days first (precipitates withdrawal). Oral naltrexone NO LONGER carries a boxed warning — hepatotoxicity is now a Warnings-section caution.
- Acamprosate
- Reduces alcohol craving; renally cleared.
- Disulfiram
- Causes an aversive reaction (flushing, nausea) with alcohol by inhibiting aldehyde dehydrogenase.
- Buprenorphine
- Partial opioid agonist (often with naloxone) for OUD; induct in mild–moderate withdrawal (COWS-guided) to avoid precipitated withdrawal.
- Methadone
- Full opioid agonist for OUD; dispensed via licensed programs; QTc risk.
- Naloxone
- Opioid antagonist; reverses overdose.
- Baseline labs for new psychiatric presentation
- TSH, CBC, CMP (electrolytes, glucose, renal/hepatic), B12/folate, urine drug screen; consider HCG in females.
- Hypothyroidism
- Can mimic depression; check TSH.
- Lithium baseline labs
- Renal function (BUN/creatinine), TSH, pregnancy test, and ECG if cardiac risk.
- St. John's Wort
- Complementary agent; induces CYP3A4 and risks serotonin syndrome with serotonergic drugs.
- First-line for treatment-resistant schizophrenia
- Clozapine.
- First-line for bipolar-depression maintenance
- Lamotrigine (slow titration).
- CBT
- Identifies and restructures cognitive distortions; uses behavioral activation; first-line for depression/anxiety.
- Cognitive distortions
- All-or-nothing thinking, catastrophizing, overgeneralization, mind reading, personalization.
- Exposure therapy
- Graded exposure to feared stimuli; first-line for phobias, OCD (ERP), and PTSD.
- Person-centered therapy (Rogers)
- Core conditions: unconditional positive regard, empathy, and congruence (genuineness).
- IPT (interpersonal therapy)
- Time-limited; targets grief, role transitions, role disputes, and interpersonal deficits.
- Behavioral therapy
- Based on conditioning; uses reinforcement and extinction.
- Classical conditioning
- Pavlov; learning by pairing stimuli (associative learning).
- Operant conditioning
- Skinner; behavior shaped by consequences (reinforcement/punishment).
- Positive vs negative reinforcement
- Positive = add a stimulus to increase a behavior; negative = remove an aversive stimulus to increase a behavior.
- DBT
- For borderline PD/self-harm; four modules: mindfulness, distress tolerance, emotion regulation, interpersonal effectiveness.
- ACT
- Acceptance and commitment therapy; builds psychological flexibility through values-based action and defusion.
- Psychodynamic therapy
- Explores unconscious conflicts; works with transference and countertransference.
- Transference
- The patient projects feelings about past figures onto the therapist.
- Countertransference
- The therapist's emotional reactions toward the patient.
- Defense mechanisms
- Unconscious coping: denial, projection, displacement, sublimation, regression, reaction formation.
- Transtheoretical model (stages of change)
- Precontemplation → contemplation → preparation → action → maintenance (± relapse).
- TTM intervention matching
- Consciousness-raising in precontemplation; commitment/planning in preparation; relapse prevention in maintenance.
- Lewin's change theory
- Unfreeze → change → refreeze.
- Erikson stage 1
- Trust vs Mistrust (infancy, 0–18 months).
- Erikson stage 2
- Autonomy vs Shame/Doubt (toddler, 1–3 years).
- Erikson stage 3
- Initiative vs Guilt (preschool, 3–6 years).
- Erikson stage 4
- Industry vs Inferiority (school-age, 6–12 years).
- Erikson stage 5
- Identity vs Role Confusion (adolescence, 12–18 years).
- Erikson stage 6
- Intimacy vs Isolation (young adulthood).
- Erikson stage 7
- Generativity vs Stagnation (middle adulthood).
- Erikson stage 8
- Integrity vs Despair (late adulthood).
- Piaget stages
- Sensorimotor (0–2), preoperational (2–7), concrete operational (7–11), formal operational (11+).
- Object permanence
- Develops in Piaget's sensorimotor stage.
- Kohlberg levels
- Preconventional, conventional, and postconventional moral reasoning.
- Attachment (Bowlby/Ainsworth)
- Secure, anxious-ambivalent, avoidant, and disorganized attachment styles.
- Mahler separation-individuation
- Process by which the infant develops a sense of self separate from the caregiver.
- Structural family therapy (Minuchin)
- Focuses on family organization, boundaries, subsystems, and hierarchy.
- Bowen family systems
- Differentiation of self, triangulation, and multigenerational transmission.
- Narrative therapy
- Externalize the problem; re-author the patient's life story.
- Therapeutic alliance
- The collaborative bond; the strongest predictor of psychotherapy outcome.
- Strongest predictor of psychotherapy outcome
- The therapeutic alliance.
- Trauma-informed care (SAMHSA 6 principles)
- Safety; Trustworthiness/Transparency; Peer support; Collaboration/Mutuality; Empowerment/Voice/Choice; Cultural/Historical/Gender issues.
- SAMHSA 4 R's
- Realize, Recognize, Respond, Resist re-traumatization.
- Boundaries
- Professional limits that protect the therapeutic relationship; crossings vs violations.
- Informed-consent elements
- Capacity, disclosure of information, understanding, and voluntariness.
- Capacity vs competency
- Capacity = a clinical, decision-specific determination by a provider; competency = a legal determination by a court.
- Four-prong capacity assessment
- Communicate a choice, understand the information, appreciate the situation/consequences, and reason about the options.
- Right to refuse treatment
- Competent patients may refuse, even life-sustaining treatment (with exceptions such as emergencies or court orders).
- HIPAA Privacy Rule
- Protects PHI; permits use/disclosure for treatment, payment, and operations without authorization.
- 42 CFR Part 2
- Stricter than HIPAA; protects substance-use-disorder treatment records.
- Tarasoff / duty to protect
- Clinician duty to protect identifiable third parties from a patient's serious threat (warn, notify police, hospitalize).
- Exceptions to confidentiality
- Duty to warn/protect, mandatory abuse reporting, danger to self/others, and a court order.
- Mandatory reporting
- Child abuse, elder abuse, and dependent-adult abuse must be reported.
- Minor consent
- Varies by state; many allow minors to consent for SUD, mental-health, reproductive, or STI care.
- Autonomy
- Respect for the patient's right to self-determination.
- Beneficence
- Acting in the patient's best interest.
- Nonmaleficence
- 'Do no harm.'
- Justice
- Fair, equitable distribution of care and resources.
- Civil-commitment criteria
- Danger to self, danger to others, or grave disability (unable to meet basic needs).
- Voluntary vs involuntary admission
- Voluntary = the patient consents and may request discharge; involuntary = legally mandated based on commitment criteria.
- Least restrictive environment
- Use the least restrictive intervention that ensures safety.
- Emergency hold
- A short-term involuntary hold (commonly ~72 hours) for evaluation when criteria are met.
- Boundary violation
- A harmful breach of professional limits (e.g., a sexual or financial relationship with a patient).
- ANA nursing-process standards
- Assessment, diagnosis, outcomes identification, planning, implementation, and evaluation.
- DSM-5-TR Cultural Formulation Interview (CFI)
- Structured questions that assess the cultural context of a patient's presentation.
- Social determinants of mental health
- Housing, income, education, discrimination, and access — drivers of mental-health disparities.
- Affirming care
- Respectful, identity-validating care for LGBTQ+ patients (correct names/pronouns; nonjudgmental).
- IDEA / Section 504
- Educational accommodations; IDEA provides IEPs for eligible students with disabilities; 504 provides accommodations.
- ADA
- Prohibits disability discrimination and mandates reasonable workplace accommodations.
- FMLA
- Up to 12 weeks of unpaid, job-protected leave for serious health conditions (including mental health).
- Psychiatric advance directive (PAD)
- A document stating treatment preferences for future psychiatric crises when capacity is lost.
- Tarasoff v. Regents
- Established the duty to protect identifiable victims.
- O'Connor v. Donaldson
- A non-dangerous person capable of surviving safely in freedom cannot be confined.
- Wyatt v. Stickney
- Established a right to treatment for the involuntarily committed.
- Rennie v. Klein / Rogers v. Commissioner
- Established committed patients' right to refuse medication (with due process).