ASCP MLS Domain 4: Hematology Welcome to your ASCP MLS Domain 4: Hematology 1. ASCP MLS: Hematology When analyzing a bone marrow aspirate, the presence of which cell type is indicative of a primary myelofibrosis diagnosis? A. Myeloblasts B. Megakaryocytes C. Erythroblasts D. Lymphocytes None 2. ASCP MLS: Hematology What is the significance of detecting BCR-ABL1 fusion gene in a patient's leukocytes? A. It indicates an acute lymphoblastic leukemia. B. It is diagnostic of chronic myeloid leukemia. C. It suggests a benign leukocytosis. D. It confirms the presence of mononucleosis. None 3. ASCP MLS: Hematology In the context of hemostasis, what role does von Willebrand factor (vWF) play in platelet adhesion? A. It binds to collagen, linking platelets to the vessel wall. B. It catalyzes the conversion of prothrombin to thrombin. C. It stabilizes fibrinogen in the clotting cascade. D. It activates platelets to release ADP and thromboxane A2. None 4. ASCP MLS: Hematology What is the primary defect in Paroxysmal Nocturnal Hemoglobinuria (PNH)? A. An intrinsic defect in the platelet aggregation pathway. B. A deficiency in clotting factor VIII. C. An acquired mutation in the PIGA gene in hematopoietic cells. D. Overproduction of erythropoietin. None 5. ASCP MLS: Hematology In a patient with suspected Disseminated Intravascular Coagulation 'DIC', which laboratory finding is typically observed? A. Increased D-dimer B. Decreased prothrombin time C. Elevated platelet count D. Reduced fibrin degradation products None 6. ASCP MLS: Hematology What is the most likely diagnosis when a blood smear shows schistocytes, helmet cells, and a negative Coombs test? A. Autoimmune hemolytic anemia B. Microangiopathic hemolytic anemia C. Hereditary spherocytosis D. G6PD deficiency None 7. ASCP MLS: Hematology The presence of Reed-Sternberg cells in lymph node biopsy is characteristic of which hematologic disorder? A. Hodgkin's lymphoma B. Non-Hodgkin's lymphoma C. Acute lymphoblastic leukemia D. Chronic lymphocytic leukemia None 8. ASCP MLS: Hematology Which of the following mutations is most commonly associated with Polycythemia Vera? A. JAK2 V617F B. BCR-ABL C. P53 D. FLT3-ITD None 9. ASCP MLS: Hematology In the evaluation of iron deficiency anemia, which of the following lab findings is most indicative of the condition? A. High ferritin with low transferrin saturation B. Low ferritin with high transferrin saturation C. High ferritin with high transferrin saturation D. Low ferritin with low transferrin saturation None 10. ASCP MLS: Hematology What is the characteristic laboratory finding in a patient with hereditary spherocytosis? A. Presence of Heinz bodies B. Increased osmotic fragility of red blood cells C. Basophilic stippling of red cells D. Target cells on blood smear None 11. ASCP MLS: Hematology Which coagulation factor is deficient in Hemophilia B? A. Factor VIII B. Factor IX C. Factor X D. Factor V None 12. ASCP MLS: Hematology The Philadelphia chromosome is a result of which of the following chromosomal translocations? A. t(9;22)(q34;q11) B. t(15;17)(q22;q12) C. t(8;14)(q24;q32) D. t(12;21)(p13;q22) None 13. ASCP MLS: Hematology In acute promyelocytic leukemia (APL), the presence of which chromosomal translocation is considered pathognomonic? A. t(9;22)(q34;q11) B. t(15;17)(q22;q12) C. t(8;21)(q22;q22) D. t(12;21)(p13;q22) None 14. ASCP MLS: Hematology What is the most common inherited cause of hypercoagulability, leading to an increased risk of venous thrombosis? A. Antithrombin deficiency B. Factor V Leiden mutation C. Protein C deficiency D. Protein S deficiency None 15. ASCP MLS: Hematology Which of the following is a key laboratory finding in Thalassemia Major? A. Macrocytosis B. Spherocytosis C. Hypochromic microcytic anemia D. Polychromasia None 16. ASCP MLS: Hematology The presence of "teardrop cells" on a peripheral blood smear is most commonly associated with which of the following conditions? A. Iron deficiency anemia B. Myelofibrosis C. Acute lymphocytic leukemia D. Vitamin B12 deficiency None 17. ASCP MLS: Hematology Auer rods are most typically associated with which type of leukemia? A. Chronic lymphocytic leukemia B. Chronic myeloid leukemia C. Acute myeloid leukemia D. Acute lymphoblastic leukemia None 18. ASCP MLS: Hematology Which of the following is the primary storage form of iron in the body? A. Transferrin B. Hemoglobin C. Ferritin D. Hemosiderin None 19. ASCP MLS: Hematology In the context of coagulation, what is the primary function of thrombin? A. Conversion of fibrinogen to fibrin B. Activation of platelets C. Degradation of clotting factors D. Synthesis of coagulation inhibitors None 20. ASCP MLS: Hematology The presence of Howell-Jolly bodies in erythrocytes is indicative of what condition? A. Hemolytic anemia B. Post-splenectomy status C. Iron deficiency anemia D. Megaloblastic anemia None 1 out of 20 Time is Up! Time's up
