ASCP MLS Domain 1: Blood Banking Welcome to your ASCP MLS Domain 1: Blood Banking 1. ASCP MLS: Blood Banking In a patient with a Bombay phenotype (hh), which of the following blood group antigens would be expected to be absent? A. A and B antigens only B. H, A, and B antigens C. H antigen only D. I antigen None 2. ASCP MLS: Blood Banking What is the primary purpose of the direct antiglobulin test (DAT)? A. Detect antibodies in the plasma B. Identify antigens on the red cell surface C. Detect in vivo coating of red cells with antibody and/or complement D. Determine blood type None 3. ASCP MLS: Blood Banking Which of the following is the most appropriate immediate action if an ABO discrepancy is identified during pre-transfusion testing? A. Perform an antibody screen B. Repeat ABO typing using a different method C. Issue O negative blood immediately D. Cancel the transfusion None 4. ASCP MLS: Blood Banking What phenotype would you expect in an individual who is homozygous for the Rh_null allele? A. Rh positive B. Rh negative C. Weak D positive D. Lack of all Rh antigens None 5. ASCP MLS: Blood Banking In the context of blood banking, the term "universal donor" refers to individuals with which blood type? A. AB positive B. O positive C. AB negative D. O negative None 6. ASCP MLS: Blood Banking Which of the following blood groups is associated with resistance to certain forms of malaria? A. A B. B C. O D. AB None 7. ASCP MLS: Blood Banking The Kell blood group system is significant in transfusion medicine because: A. It is involved in the most severe form of hemolytic disease of the fetus and newborn (HDFN) B. Anti-Kell antibodies are naturally occurring C. It contains the most antigens of any blood group system D. It is the primary system used for blood typing None 8. ASCP MLS: Blood Banking The presence of which antigen is tested to differentiate between weak D and partial D phenotypes? A. C antigen B. E antigen C. D antigen D. e antigen None 9. ASCP MLS: Blood Banking In transfusion medicine, which antibody is typically implicated in cases of delayed hemolytic transfusion reactions? A. Anti-A1 B. Anti-Kell C. Anti-Jka D. Anti-Fya None 10. ASCP MLS: Blood Banking What is the most likely blood type of a child born to a mother with type O blood and a father with type AB blood? A. Type O B. Type A C. Type B D. Type AB None 11. ASCP MLS: Blood Banking Which of the following is a key feature of the Duffy blood group system? A. It is the primary system used for crossmatching. B. Duffy antigens act as receptors for Plasmodium vivax. C. It contains the most antigens of any blood group system. D. It is involved in the ABO incompatibility reactions. None 12. ASCP MLS: Blood Banking What blood component is preferred for transfusion in patients with IgA deficiency to prevent anaphylactic reactions? A. Platelet concentrate B. Fresh frozen plasma C. IgA deficient plasma D. Washed red blood cells None 13. ASCP MLS: Blood Banking The Lewis blood group system is unique because: A. Lewis antigens are not produced by erythrocytes. B. It has no clinical significance in transfusion medicine. C. Lewis antibodies are naturally occurring and clinically insignificant. D. It is the only blood group system not detected by standard serological methods. None 14. ASCP MLS: Blood Banking In the Rh blood group system, which antigen is most commonly associated with hemolytic disease of the fetus and newborn (HDFN)? A. c antigen B. E antigen C. D antigen D. e antigen None 15. ASCP MLS: Blood Banking Which of the following is true about the P1 antigen? A. It is associated with resistance to HIV. B. P1 negative individuals can produce anti-P1 naturally. C. It is a high-incidence antigen found in all populations. D. The presence of P1 is linked to a decreased risk of urinary tract infections. None 16. ASCP MLS: Blood Banking What is the most likely cause of a positive direct antiglobulin test (DAT) in a newborn? A. ABO incompatibility B. Exposure to maternal medications C. Infection D. Rh incompatibility None 17. ASCP MLS: Blood Banking Which antibody screening result would you expect in a patient with the Chido/Rodgers (Ch/Rg) null phenotype? A. Positive for anti-Ch B. Positive for anti-Rg C. Negative for both anti-Ch and anti-Rg D. Positive for anti-Ch and anti-Rg None 18. ASCP MLS: Blood Banking What is the significance of detecting anti-E in a patient's serum during pre-transfusion testing? A. It indicates an immediate need to transfuse E-negative blood. B. It is clinically insignificant and requires no special action. C. It necessitates the provision of antigen-matched blood to prevent a hemolytic transfusion reaction. D. It requires confirmation with molecular testing. None 19. ASCP MLS: Blood Banking What is the most likely cause of a positive direct antiglobulin test (DAT) in a newborn? A. ABO incompatibility B. Exposure to maternal medications C. Infection D. Rh incompatibility None 20. ASCP MLS: Blood Banking Which of the following is a key feature of the Duffy blood group system? A. It is the primary system used for crossmatching. B. Duffy antigens act as receptors for Plasmodium vivax. C. It contains the most antigens of any blood group system. D. It is involved in the ABO incompatibility reactions. None 1 out of 20 Time is Up! Time's up
